Abstract
Phenytoin was given intravenously in 37 patients with cardiac arrhythmias—21 had acute myocardial infarction and 16 had other conditions. There was a favourable response in 18 of the 21 cases with acute myocardial infarction, with a return to sinus rhythm in six of the nine cases with supraventricular arrhythmias, and a return to sinus rhythm in 10 of the 12 cases of ventricular arrhythmias, the remaining two showing a significant reduction in the number of ventricular extra-systoles.
In the second group of 16 cases which had various causes there was a satisfactory response in only six. Digitalis played no part in producing any of the arrhythmias. Phenytoin was used orally for suppressing and preventing abnormal rhythm in five patients, and three of these responded favourably. The number of patients treated orally is too small to draw any definite conclusion.
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- BRENNER O., DAVISON P. H., EVANS D. W. TOXICITY OF QUINIDINE. Lancet. 1964 Nov 28;2(7370):1184–1184. doi: 10.1016/s0140-6736(64)92721-7. [DOI] [PubMed] [Google Scholar]
- Bigger J. T., Jr, Schmidt D. H., Kutt H. Relationship between the plasma level of diphenylhydantoin sodium and its cardiac antiarrhythmic effects. Circulation. 1968 Aug;38(2):363–374. doi: 10.1161/01.cir.38.2.363. [DOI] [PubMed] [Google Scholar]
- Hansen J. M., Kristensen M., Skovsted L., Christensen L. K. Dicoumarol-induced diphenylhydantoin intoxication. Lancet. 1966 Jul 30;2(7457):265–266. doi: 10.1016/s0140-6736(66)92547-5. [DOI] [PubMed] [Google Scholar]
- Helfant R. H., Scherlag B. J., Damato A. N. The electrophysiological properties of diphenylhydantoin sodium as compared to procaine amide in the normal and digitalis-intoxicated heart. Circulation. 1967 Jul;36(1):108–118. doi: 10.1161/01.cir.36.1.108. [DOI] [PubMed] [Google Scholar]
- Lieberson A. D., Schumacher R. R., Childress R. H., Boyd D. L., Williams J. F., Jr Effect of diphenylhydantoin on left ventricular function in patients with heart disease. Circulation. 1967 Nov;36(5):692–699. doi: 10.1161/01.cir.36.5.692. [DOI] [PubMed] [Google Scholar]
- Mixter C. G., 3rd, Moran J. M., Austen W. G. Cardiac and peripheral vascular effects of diphenylhydantoin sodium. Am J Cardiol. 1966 Mar;17(3):332–338. doi: 10.1016/0002-9149(66)90216-5. [DOI] [PubMed] [Google Scholar]
- ORAM S., DAVIES J. P. FURTHER EXPERIENCE OF ELECTRICAL CONVERSION OF ATRIAL FIBRILLATION TO SINUS RHYTHM: ANALYSIS OF 100 PATIENTS. Lancet. 1964 Jun 13;1(7346):1294–1298. doi: 10.1016/s0140-6736(64)91692-7. [DOI] [PubMed] [Google Scholar]
- Rosen M., Lisak R., Rubin I. L. Diphenylhydantoin in cardiac arrhythmias. Am J Cardiol. 1967 Nov;20(5):674–678. doi: 10.1016/0002-9149(67)90011-2. [DOI] [PubMed] [Google Scholar]
- Unger A. H., Sklaroff H. J. Fatalities following intravenous use of sodium diphenylhydantoin for cardiac arrhythmias. Report of two cases. JAMA. 1967 Apr 24;200(4):335–336. [PubMed] [Google Scholar]