Abstract
Four patients with cryptococcal meningitis were treated with amphotericin B colloidal dispersion because of nephrotoxicity from prior treatment with conventional amphotericin B. The limited experience presented here suggests that amphotericin B colloidal dispersion is efficacious for the treatment of cryptococcal meningitis, despite being undetectable in cerebrospinal fluid, and offers a potential therapeutic alternative for patients who cannot tolerate conventional amphotericin B.
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- Coker R. J., Viviani M., Gazzard B. G., Du Pont B., Pohle H. D., Murphy S. M., Atouguia J., Champalimaud J. L., Harris J. R. Treatment of cryptococcosis with liposomal amphotericin B (AmBisome) in 23 patients with AIDS. AIDS. 1993 Jun;7(6):829–835. doi: 10.1097/00002030-199306000-00011. [DOI] [PubMed] [Google Scholar]
- Dismukes W. E., Cloud G., Gallis H. A., Kerkering T. M., Medoff G., Craven P. C., Kaplowitz L. G., Fisher J. F., Gregg C. R., Bowles C. A. Treatment of cryptococcal meningitis with combination amphotericin B and flucytosine for four as compared with six weeks. N Engl J Med. 1987 Aug 6;317(6):334–341. doi: 10.1056/NEJM198708063170602. [DOI] [PubMed] [Google Scholar]
- Gallis H. A., Drew R. H., Pickard W. W. Amphotericin B: 30 years of clinical experience. Rev Infect Dis. 1990 Mar-Apr;12(2):308–329. doi: 10.1093/clinids/12.2.308. [DOI] [PubMed] [Google Scholar]
- Hostetler J. S., Clemons K. V., Hanson L. H., Stevens D. A. Efficacy and safety of amphotericin B colloidal dispersion compared with those of amphotericin B deoxycholate suspension for treatment of disseminated murine cryptococcosis. Antimicrob Agents Chemother. 1992 Dec;36(12):2656–2660. doi: 10.1128/aac.36.12.2656. [DOI] [PMC free article] [PubMed] [Google Scholar]