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. 1969 Dec 20;4(5685):715–717. doi: 10.1136/bmj.4.5685.715

Handling of induced hypercalcaemia in hyperthyroidism

P Lim, E Jacob, O T Khoo
PMCID: PMC1630122  PMID: 5354875

Abstract

The mean serum calcium of 13 hyperthyroid patients was found to be significantly higher than that of controls matched for sex and age, though none of the patients' values were outside the normal range. Nevertheless, these patients responded very promptly to hypercalcaemia (induced by an intravenous calcium load), and their serum calcium returned to normal much more rapidly compared with the matched controls. There was also increased retention of intravenous calcium load, possibly owing to increased calcitonin production. Calcium infusion may be useful in treating bone diseases in which increased bone resorption exceeds bone accretion.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adams P., Jowsey J. Bone and mineral metabolism in hyperthyroidism: an experimental study. Endocrinology. 1967 Oct;81(4):735–740. doi: 10.1210/endo-81-4-735. [DOI] [PubMed] [Google Scholar]
  2. Aub J. C., Albright F., Bauer W., Rossmeisl E. STUDIES OF CALCIUM AND PHOSPHORUS METABOLISM: VI. In Hypoparathyroidism and Chronic Steatorrhea with Tetany with Special Consideration of the Therapeutic Effect of Thyroid. J Clin Invest. 1932 Jan;11(1):211–234. doi: 10.1172/JCI100404. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bijvoet O. L., van der Sluys Veer J., Jansen A. P. Effects of calcitonin on patients with Paget's disease, thyrotoxicosis, or hypercalcaemia. Lancet. 1968 Apr 27;1(7548):876–881. doi: 10.1016/s0140-6736(68)90236-5. [DOI] [PubMed] [Google Scholar]
  4. CLERKIN E. P., HAAS H. G., MINTZ D. H., MELONI C. R., CANARY J. J. OSTEOMALACIA IN THYROTOXICOSIS. Metabolism. 1964 Feb;13:161–171. doi: 10.1016/0026-0495(64)90129-5. [DOI] [PubMed] [Google Scholar]
  5. Cope O., Donaldson G. A. RELATION OF THYROID AND PARATHYROID GLANDS TO CALCIUM AND PHOSPHORUS METABOLISM. STUDY OF A CASE WITH COEXISTENT HYPOPARATHYROIDISM AND HYPERTHYROIDISM. J Clin Invest. 1937 May;16(3):329–341. doi: 10.1172/JCI100861. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. EPSTEIN F. H., FREEDMAN L. R., LEVITIN H. Hypercalcemia, nephrocalcinosis and reversible renal insufficiency associated with hyperthyroidism. N Engl J Med. 1958 Apr 17;258(16):782–785. doi: 10.1056/NEJM195804172581604. [DOI] [PubMed] [Google Scholar]
  7. Frizel D., Malleson A., Marks V. Plasma levels of ionised calcium and magnesium in thyroid disease. Lancet. 1967 Jun 24;1(7504):1360–1361. doi: 10.1016/s0140-6736(67)91766-7. [DOI] [PubMed] [Google Scholar]
  8. Gudmundsson T. V., Woodhouse N. J., Osafo T. D., Galante L., Matthews E. W., MacIntyre I., Kenny A. D., Wiggins R. C. Plasma-calcitonin in man. Lancet. 1969 Mar 1;1(7592):443–446. doi: 10.1016/s0140-6736(69)91482-2. [DOI] [PubMed] [Google Scholar]
  9. KLEEMAN C. R., TUTTLE S., BASSETT S. H. Metabolic observations in a case of thyrotoxicosis with hypercalcemia. J Clin Endocrinol Metab. 1958 May;18(5):477–491. doi: 10.1210/jcem-18-5-477. [DOI] [PubMed] [Google Scholar]
  10. KRANE S. M., BROWNELL G. L., STANBURY J. B., CORRIGAN H. The effect of thyroid disease on calcium metabolism in man. J Clin Invest. 1956 Aug;35(8):874–887. doi: 10.1172/JCI103340. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mittleman R., Chausmer A., Bellavia J., Wallach S. Thyrocalcitonin activity in hypercalcemia produced by calcium salts, parathyroid hormone and vitamin D. Endocrinology. 1967 Sep;81(3):599–604. doi: 10.1210/endo-81-3-599. [DOI] [PubMed] [Google Scholar]
  12. Sturtridge W. C., Kumar M. A. Assay of calcitonin in human plasma. Lancet. 1968 Apr 6;1(7545):725–726. doi: 10.1016/s0140-6736(68)92167-3. [DOI] [PubMed] [Google Scholar]

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