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. 1995 Dec;39(12):2798–2800. doi: 10.1128/aac.39.12.2798

In vitro antimicrobial effect against Streptococcus pneumoniae of adding rifampin to penicillin, ceftriaxone, or 1-ofloxacin.

K P Giron 1, M E Gross 1, D M Musher 1, T W Williams Jr 1, R A Tharappel 1
PMCID: PMC163033  PMID: 8593023

Abstract

Adding rifampin to penicillin or l-ofloxacin diminished the rate at which these antibiotics killed 21 clinical isolates isolates of Streptococcus pneumoniae in vitro. A less pronounced inhibitory effect was observed when rifampin was added to ceftriaxone. Synergy was not observed for any bacterial isolate. The in vitro demonstration of indifference or antagonism using these antibiotic combinations argues against the empirical addition of rifampin to beta-lactams or fluoroquinolones in treating serious pneumococcal infections.

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Selected References

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