Skip to main content
NCBI home page
British Medical Journal logoLink to British Medical Journal
. 1969 Nov 29;4(5682):522–525. doi: 10.1136/bmj.4.5682.522

Use of antilymphocyte globulin after cadaveric renal transplantation

P B Doak, N T Dalton, J Meredith, J Z Montgomerie, J D K North
PMCID: PMC1630331  PMID: 4901345

Abstract

Antilymphocyte globulin (A.L.G.) was prepared by injecting fresh frozen splenic cells subcutaneously into horses. The IgG fraction of the serum was concentrated by a batch technique using diethylaminoethanol-Sephadex. Fourteen patients given this material by intramuscular injection after cadaveric renal transplants, in addition to azathioprine and prednisone, had less evidence of rejection compared with patients previously treated with azathioprine and prednisone only, despite a reduction of the mean daily prednisone dose from 65 to 45 mg. Toxicity, especially local reaction, fever, and hypotension, limited the amount of A.L.G. that was given.

Full text

PDF
522

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bach J. F., Dardenne M., Dormont J., Antoine B. A new in vitro test evaluating anti-lymphocyte serum potency. Transplant Proc. 1969 Mar;1(1):403–407. [PubMed] [Google Scholar]
  2. Balner H., Dersjant H., van Bekkum D. W. Studies in immuno-suppression. Methods to evaluate anti-human lymphocyte sera. Transplant Proc. 1969 Mar;1(1):629–637. [PubMed] [Google Scholar]
  3. Balner H., Eysvoogel V. P., Cleton F. J. Testing of anti-human lymphocyte sera in chimpanzees and lower primates. Lancet. 1968 Jan 6;1(7532):19–22. doi: 10.1016/s0140-6736(68)90009-3. [DOI] [PubMed] [Google Scholar]
  4. CULLIFORD B. J. PRECIPITIN REACTIONS IN FORENSIC PROBLEMS. A NEW METHOD FOR PRECIPITIN REACTIONS ON FORENSIC BLOOD, SEMEN AND SALIVA STAINS. Nature. 1964 Mar 14;201:1092–1093. doi: 10.1038/2011092a0. [DOI] [PubMed] [Google Scholar]
  5. Howell E., Perkins H. A. Microtiter modification of th complement fixation test for platelet antibodies. Transfusion. 1968 Jan-Feb;8(1):33–36. doi: 10.1111/j.1537-2995.1968.tb02384.x. [DOI] [PubMed] [Google Scholar]
  6. James K. Anti-lymphocytic antibody--a review. Clin Exp Immunol. 1967 Nov;2(6):615–631. [PMC free article] [PubMed] [Google Scholar]
  7. Jeejeebhoy H. F., Vela-Martinez J. M. Studies on the mode of action of heterologous anti-lymphocyte plasma. II. The effect of anti-lymphocyte plasma on lymphocyte counts. Transplantation. 1968 Mar;6(2):149–159. doi: 10.1097/00007890-196803000-00001. [DOI] [PubMed] [Google Scholar]
  8. Kashiwagi N., Brantigan C. O., Brettschneider L., Groth C. G., Starzl T. E. Clinical reactions and serologic changes after the administration of heterologous antilymphocyte globulin to human recipients of renal homografts. Ann Intern Med. 1968 Feb;68(2):275–286. doi: 10.7326/0003-4819-68-2-275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Konomi K., Deodhar S. D., Tung K. S., Nakamoto S. Immunosuppression with antilymphocyte globulin in clinical renal transplantation. Surg Forum. 1968;19:194–195. [PubMed] [Google Scholar]
  10. Lance E. M., Medawar P. B. Survival of skin heterografts under treatment with antilymphocytic serum. Lancet. 1968 Jun 1;1(7553):1174–1176. doi: 10.1016/s0140-6736(68)91868-0. [DOI] [PubMed] [Google Scholar]
  11. Martin W. J., Miller J. F. Assay for the immunosuppressive capacity of antilymphocyte serum based on its action on thymus-derived cells. Int Arch Allergy Appl Immunol. 1969;35(2):163–178. doi: 10.1159/000230169. [DOI] [PubMed] [Google Scholar]
  12. PAYNE R. AGGLUTINATION TECHNIQUE FOR DEMONSTRATION OF LEUKOCYTE ISOANTIGENS IN MAN. Methods Med Res. 1964;10:27–34. [PubMed] [Google Scholar]
  13. Sheil A. G., Rogers J. H. Antilymphocyte serum: a review with report of the current clinical situation in Australia. Med J Aust. 1969 Jun 28;1(26):1370–1375. doi: 10.5694/j.1326-5377.1969.tb62411.x. [DOI] [PubMed] [Google Scholar]
  14. Tsirimbas A. D., Pichlmayr R., Hornung B., Pfisterer H., Thierfelder S., Brendel W., Stich W. Therapeutische Wrikungen Von heterologem Antihumanlympnocytenserum (AHLS0 bei chronischer lymphaischer Leukämie. Klin Wochenschr. 1968 Jun 1;46(11):583–586. doi: 10.1007/BF01747837. [DOI] [PubMed] [Google Scholar]
  15. Woodruff M. F., Nolan B., Robson J. S., MacDonald M. K. Renal transplantation in man. Experience in 35 cases. Lancet. 1969 Jan 4;1(7584):6–12. doi: 10.1016/s0140-6736(69)90982-9. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES