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. 1996 Jan;40(1):1–5. doi: 10.1128/aac.40.1.1

Tetracycline resistance mediated by ribosomal protection.

D E Taylor 1, A Chau 1
PMCID: PMC163045  PMID: 8787868

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Selected References

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  1. AEvarsson A., Brazhnikov E., Garber M., Zheltonosova J., Chirgadze Y., al-Karadaghi S., Svensson L. A., Liljas A. Three-dimensional structure of the ribosomal translocase: elongation factor G from Thermus thermophilus. EMBO J. 1994 Aug 15;13(16):3669–3677. doi: 10.1002/j.1460-2075.1994.tb06676.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Buck M. A., Cooperman B. S. Single protein omission reconstitution studies of tetracycline binding to the 30S subunit of Escherichia coli ribosomes. Biochemistry. 1990 Jun 5;29(22):5374–5379. doi: 10.1021/bi00474a024. [DOI] [PubMed] [Google Scholar]
  3. Burdett V. Nucleotide sequence of the tet(M) gene of Tn916. Nucleic Acids Res. 1990 Oct 25;18(20):6137–6137. doi: 10.1093/nar/18.20.6137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Burdett V. Purification and characterization of Tet(M), a protein that renders ribosomes resistant to tetracycline. J Biol Chem. 1991 Feb 15;266(5):2872–2877. [PubMed] [Google Scholar]
  5. Burdett V. Streptococcal tetracycline resistance mediated at the level of protein synthesis. J Bacteriol. 1986 Feb;165(2):564–569. doi: 10.1128/jb.165.2.564-569.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Burdett V. tRNA modification activity is necessary for Tet(M)-mediated tetracycline resistance. J Bacteriol. 1993 Nov;175(22):7209–7215. doi: 10.1128/jb.175.22.7209-7215.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Charpentier E., Gerbaud G., Courvalin P. Characterization of a new class of tetracycline-resistance gene tet(S) in Listeria monocytogenes BM4210. Gene. 1993 Sep 6;131(1):27–34. doi: 10.1016/0378-1119(93)90665-p. [DOI] [PubMed] [Google Scholar]
  8. Charpentier E., Gerbaud G., Courvalin P. Presence of the Listeria tetracycline resistance gene tet(S) in Enterococcus faecalis. Antimicrob Agents Chemother. 1994 Oct;38(10):2330–2335. doi: 10.1128/aac.38.10.2330. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Connolly D. M., Winkler M. E. Structure of Escherichia coli K-12 miaA and characterization of the mutator phenotype caused by miaA insertion mutations. J Bacteriol. 1991 Mar;173(5):1711–1721. doi: 10.1128/jb.173.5.1711-1721.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Czworkowski J., Wang J., Steitz T. A., Moore P. B. The crystal structure of elongation factor G complexed with GDP, at 2.7 A resolution. EMBO J. 1994 Aug 15;13(16):3661–3668. doi: 10.1002/j.1460-2075.1994.tb06675.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Devereux J., Haeberli P., Smithies O. A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387–395. doi: 10.1093/nar/12.1part1.387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Doyle D., McDowall K. J., Butler M. J., Hunter I. S. Characterization of an oxytetracycline-resistance gene, otrA, of Streptomyces rimosus. Mol Microbiol. 1991 Dec;5(12):2923–2933. doi: 10.1111/j.1365-2958.1991.tb01852.x. [DOI] [PubMed] [Google Scholar]
  13. Forchhammer K., Rücknagel K. P., Böck A. Purification and biochemical characterization of SELB, a translation factor involved in selenoprotein synthesis. J Biol Chem. 1990 Jun 5;265(16):9346–9350. [PubMed] [Google Scholar]
  14. Gefter M. L., Russell R. L. Role modifications in tyrosine transfer RNA: a modified base affecting ribosome binding. J Mol Biol. 1969 Jan 14;39(1):145–157. doi: 10.1016/0022-2836(69)90339-8. [DOI] [PubMed] [Google Scholar]
  15. Grewal J., Manavathu E. K., Taylor D. E. Effect of mutational alteration of Asn-128 in the putative GTP-binding domain of tetracycline resistance determinant Tet(O) from Campylobacter jejuni. Antimicrob Agents Chemother. 1993 Dec;37(12):2645–2649. doi: 10.1128/aac.37.12.2645. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Hou Y., Lin Y. P., Sharer J. D., March P. E. In vivo selection of conditional-lethal mutations in the gene encoding elongation factor G of Escherichia coli. J Bacteriol. 1994 Jan;176(1):123–129. doi: 10.1128/jb.176.1.123-129.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Johanson U., Hughes D. Comparison of the complete sequence of the str operon in Salmonella typhimurium and Escherichia coli. Gene. 1992 Oct 12;120(1):93–98. doi: 10.1016/0378-1119(92)90014-g. [DOI] [PubMed] [Google Scholar]
  18. Johanson U., Hughes D. Fusidic acid-resistant mutants define three regions in elongation factor G of Salmonella typhimurium. Gene. 1994 May 27;143(1):55–59. doi: 10.1016/0378-1119(94)90604-1. [DOI] [PubMed] [Google Scholar]
  19. Kjeldgaard M., Nyborg J. Refined structure of elongation factor EF-Tu from Escherichia coli. J Mol Biol. 1992 Feb 5;223(3):721–742. doi: 10.1016/0022-2836(92)90986-t. [DOI] [PubMed] [Google Scholar]
  20. Levy S. B. Active efflux mechanisms for antimicrobial resistance. Antimicrob Agents Chemother. 1992 Apr;36(4):695–703. doi: 10.1128/aac.36.4.695. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Levy S. B., McMurry L. M., Burdett V., Courvalin P., Hillen W., Roberts M. C., Taylor D. E. Nomenclature for tetracycline resistance determinants. Antimicrob Agents Chemother. 1989 Aug;33(8):1373–1374. doi: 10.1128/aac.33.8.1373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Manavathu E. K., Fernandez C. L., Cooperman B. S., Taylor D. E. Molecular studies on the mechanism of tetracycline resistance mediated by Tet(O). Antimicrob Agents Chemother. 1990 Jan;34(1):71–77. doi: 10.1128/aac.34.1.71. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Manavathu E. K., Hiratsuka K., Taylor D. E. Nucleotide sequence analysis and expression of a tetracycline-resistance gene from Campylobacter jejuni. Gene. 1988;62(1):17–26. doi: 10.1016/0378-1119(88)90576-8. [DOI] [PubMed] [Google Scholar]
  24. Martin P., Trieu-Cuot P., Courvalin P. Nucleotide sequence of the tetM tetracycline resistance determinant of the streptococcal conjugative shuttle transposon Tn1545. Nucleic Acids Res. 1986 Sep 11;14(17):7047–7058. doi: 10.1093/nar/14.17.7047. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Nikolich M. P., Shoemaker N. B., Salyers A. A. A Bacteroides tetracycline resistance gene represents a new class of ribosome protection tetracycline resistance. Antimicrob Agents Chemother. 1992 May;36(5):1005–1012. doi: 10.1128/aac.36.5.1005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Pang Y., Brown B. A., Steingrube V. A., Wallace R. J., Jr, Roberts M. C. Tetracycline resistance determinants in Mycobacterium and Streptomyces species. Antimicrob Agents Chemother. 1994 Jun;38(6):1408–1412. doi: 10.1128/aac.38.6.1408. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Roberts M. C. Epidemiology of tetracycline-resistance determinants. Trends Microbiol. 1994 Oct;2(10):353–357. doi: 10.1016/0966-842x(94)90610-6. [DOI] [PubMed] [Google Scholar]
  28. Sanchez-Pescador R., Brown J. T., Roberts M., Urdea M. S. Homology of the TetM with translational elongation factors: implications for potential modes of tetM-conferred tetracycline resistance. Nucleic Acids Res. 1988 Feb 11;16(3):1218–1218. doi: 10.1093/nar/16.3.1218. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Sanchez-Pescador R., Brown J. T., Roberts M., Urdea M. S. The nucleotide sequence of the tetracycline resistance determinant tetM from Ureaplasma urealyticum. Nucleic Acids Res. 1988 Feb 11;16(3):1216–1217. doi: 10.1093/nar/16.3.1216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Sloan J., McMurry L. M., Lyras D., Levy S. B., Rood J. I. The Clostridium perfringens Tet P determinant comprises two overlapping genes: tetA(P), which mediates active tetracycline efflux, and tetB(P), which is related to the ribosomal protection family of tetracycline-resistance determinants. Mol Microbiol. 1994 Jan;11(2):403–415. doi: 10.1111/j.1365-2958.1994.tb00320.x. [DOI] [PubMed] [Google Scholar]
  31. Speer B. S., Salyers A. A. Novel aerobic tetracycline resistance gene that chemically modifies tetracycline. J Bacteriol. 1989 Jan;171(1):148–153. doi: 10.1128/jb.171.1.148-153.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Su Y. A., He P., Clewell D. B. Characterization of the tet(M) determinant of Tn916: evidence for regulation by transcription attenuation. Antimicrob Agents Chemother. 1992 Apr;36(4):769–778. doi: 10.1128/aac.36.4.769. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Taylor D. E., Courvalin P. Mechanisms of antibiotic resistance in Campylobacter species. Antimicrob Agents Chemother. 1988 Aug;32(8):1107–1112. doi: 10.1128/aac.32.8.1107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Taylor D. E., Hiratsuka K., Ray H., Manavathu E. K. Characterization and expression of a cloned tetracycline resistance determinant from Campylobacter jejuni plasmid pUA466. J Bacteriol. 1987 Jul;169(7):2984–2989. doi: 10.1128/jb.169.7.2984-2989.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Tubulekas I., Hughes D. A single amino acid substitution in elongation factor Tu disrupts interaction between the ternary complex and the ribosome. J Bacteriol. 1993 Jan;175(1):240–250. doi: 10.1128/jb.175.1.240-250.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Wang Y., Taylor D. E. A DNA sequence upstream of the tet(O) gene is required for full expression of tetracycline resistance. Antimicrob Agents Chemother. 1991 Oct;35(10):2020–2025. doi: 10.1128/aac.35.10.2020. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Yanofsky C. Mutations affecting tRNATrp and its charging and their effect on regulation of transcription termination at the attenuator of the tryptophan operon. J Mol Biol. 1977 Jul 15;113(4):663–677. doi: 10.1016/0022-2836(77)90229-7. [DOI] [PubMed] [Google Scholar]

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