Abstract
In a combined Norwegian and British study of the age at death from coronary heart disease of heterozygotes for familial hypercholesterolaemia (FH) the correlation coefficients within families for 43 sib pairs was 0-70 and for 14 first cousin pairs 0-61. There was no significant correlation between the age at death and serum cholesterol concentration in either series. The intrafamilial correlations suggest that information about the age at death from coronary heart disease in heterozygotes within families may have some prognostic value and may also be interpreted as evidence for genetic heterogeneity in FH.
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Selected References
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- EPSTEIN F. H., BLOCK W. D., HAND E. A., FRANCIS T., Jr Familial hypercholesterolemia, xanthomatosis and coronary heart disease. Am J Med. 1959 Jan;26(1):39–53. doi: 10.1016/0002-9343(59)90325-0. [DOI] [PubMed] [Google Scholar]
- Heiberg A., Berg K. The inheritance of hyperlipoproteinaemia with xanthomatosis. A study of 132 kindreds. Clin Genet. 1976 Feb;9(2):203–233. doi: 10.1111/j.1399-0004.1976.tb01569.x. [DOI] [PubMed] [Google Scholar]
- Heiberg A. Inheritance of xanthomatosis and hyper-beta-lipoproteinaemia. A study of 7 large kindreds. Clin Genet. 1976 Jan;9(1):92–111. doi: 10.1111/j.1399-0004.1976.tb01554.x. [DOI] [PubMed] [Google Scholar]
- Heiberg A. The risk of atherosclerotic vascular disease in subjects with xanthomatosis. Acta Med Scand. 1975 Oct;198(4):249–261. doi: 10.1111/j.0954-6820.1975.tb19536.x. [DOI] [PubMed] [Google Scholar]
- Higgins M. J., Lecamwasam D. S., Galton D. J. A new type of familial hypercholesterolaemia. Lancet. 1975 Oct 18;2(7938):737–740. doi: 10.1016/s0140-6736(75)90723-0. [DOI] [PubMed] [Google Scholar]
- Jensen J., Blankenhorn D. H., Kornerup V. Coronary disease in familial hypercholesterolemia. Circulation. 1967 Jul;36(1):77–82. doi: 10.1161/01.cir.36.1.77. [DOI] [PubMed] [Google Scholar]
- KANNEL W. B., DAWBER T. R., FRIEDMAN G. D., GLENNON W. E., MCNAMARA P. M. RISK FACTORS IN CORONARY HEART DISEASE. AN EVALUATION OF SEVERAL SERUM LIPIDS AS PREDICTORS OF CORONARY HEART DISEASE; THE FRAMINGHAM STUDY. Ann Intern Med. 1964 Nov;61:888–899. doi: 10.7326/0003-4819-61-5-888. [DOI] [PubMed] [Google Scholar]
- Slack J. Risks of ischaemic heart-disease in familial hyperlipoproteinaemic states. Lancet. 1969 Dec 27;2(7635):1380–1382. doi: 10.1016/s0140-6736(69)90930-1. [DOI] [PubMed] [Google Scholar]