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Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1996 Jan;40(1):221–224. doi: 10.1128/aac.40.1.221

Characterization of the plasmidic beta-lactamase CMY-2, which is responsible for cephamycin resistance.

A Bauernfeind 1, I Stemplinger 1, R Jungwirth 1, H Giamarellou 1
PMCID: PMC163087  PMID: 8787910

Abstract

The phenotype of Klebsiella pneumoniae HEL-1 indicates a plasmidic cephamycinase gene (blaCMY-2). Its sequence shows one open reading frame coding for a protein of 381 amino acids. CMY-2 is classified as class C beta-lactamase that is closely related to the plasmidic enzymes BIL-1 and LAT-1 and the chromosomal AmpC of Citrobacter freundii. The blaCMY-2 gene possibly was translocated onto a plasmid of C. freundii which spread to K. pneumoniae.

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Selected References

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