Abstract
A three-year study of febrile convulsions in Oxford with comprehensive notification from general practice and hospitals showed a 3% risk for all children of suffering at least one febrile convulsion by the age of 5 years. Children were most at risk between 6 and 27 months, and febrile convulsions were most likely to be prolonged in children aged 9-15 months. The association between febrile convulsions and primary immunisations in the preceding 28 days was compared in case and control children, matched for age and sex. Results suggested that such association was a chance relationship with age. If association was direct, the febrile convulsion rates per 1000 immunisation doses were estimated as follows: diphtheria, pertussis, tetanus--0-09 per 1000; poliomyelitis--0-6 per 1000; and measles--0-9 per 1000. Hence if any of these vaccines had a secific causal relationship with febrile convulsions, these rates would probably have been much higher.
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Selected References
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- Kulenkampff M., Schwartzman J. S., Wilson J. Neurological complications of pertussis inoculation. Arch Dis Child. 1974 Jan;49(1):46–49. doi: 10.1136/adc.49.1.46. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Landrigan P. J., Witte J. J. Neurologic disorders following live measles-virus vaccination. JAMA. 1973 Mar 26;223(13):1459–1462. [PubMed] [Google Scholar]
- Melchior J. C. Infantile spasms and early immunization against whooping cough. Danish survey from 1970 to 1975. Arch Dis Child. 1977 Feb;52(2):134–137. doi: 10.1136/adc.52.2.134. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nelson K. B., Ellenberg J. H. Predictors of epilepsy in children who have experienced febrile seizures. N Engl J Med. 1976 Nov 4;295(19):1029–1033. doi: 10.1056/NEJM197611042951901. [DOI] [PubMed] [Google Scholar]
- Stewart G. T. Vaccination against whooping-cough. Efficacy versus risks. Lancet. 1977 Jan 29;1(8005):234–237. doi: 10.1016/s0140-6736(77)91028-5. [DOI] [PubMed] [Google Scholar]
- Van der Berg B. J., Yerushalmy J. Studies on convulsive disorders in young children. I. Incidence of febrile and nonfebrile convulsions by age and other factors. Pediatr Res. 1969 Jul;3(4):298–304. doi: 10.1203/00006450-196907000-00005. [DOI] [PubMed] [Google Scholar]
- van den Berg B. J. Studies on convulsive disorders in young children. IV: Incidence of convulsions among siblings. Dev Med Child Neurol. 1974 Aug;16(4):457–464. doi: 10.1111/j.1469-8749.1974.tb03370.x. [DOI] [PubMed] [Google Scholar]