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. 1996 Jan;40(1):263–266. doi: 10.1128/aac.40.1.263

Comparison of fluconazole and amphotericin B for treatment of experimental Candida albicans endocarditis in rabbits.

K Chemlal 1, L Saint-Julien 1, V Joly 1, R Farinotti 1, N Seta 1, P Yeni 1, C Carbon 1
PMCID: PMC163098  PMID: 8787921

Abstract

Amphotericin B (AmB) and fluconazole, administered intraperitoneally for 7 days, were compared in a rabbit model for Candida albicans endocarditis. When given early, AmB was more effective than fluconazole for reducing CFU counts in vegetations (P < 0.01) and kidneys. Forty-eight hours after the last dose, AmB was still detected in all vegetations whereas fluconazole was detected in only one case.

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Selected References

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  1. Anaissie E., Bodey G. P., Kantarjian H., David C., Barnett K., Bow E., Defelice R., Downs N., File T., Karam G. Fluconazole therapy for chronic disseminated candidiasis in patients with leukemia and prior amphotericin B therapy. Am J Med. 1991 Aug;91(2):142–150. doi: 10.1016/0002-9343(91)90006-j. [DOI] [PubMed] [Google Scholar]
  2. Davis J. M., Moss A. J., Schenk E. A. Tricuspid candida endocarditis complicating a permanently implanted transvenous pacemaker. Am Heart J. 1969 Jun;77(6):818–821. doi: 10.1016/0002-8703(69)90418-9. [DOI] [PubMed] [Google Scholar]
  3. Drutz D. J. In vitro antifungal susceptibility testing and measurement of levels of antifungal agents in body fluids. Rev Infect Dis. 1987 Mar-Apr;9(2):392–397. doi: 10.1093/clinids/9.2.392. [DOI] [PubMed] [Google Scholar]
  4. Durack D. T., Beeson P. B. Experimental bacterial endocarditis. I. Colonization of a sterile vegetation. Br J Exp Pathol. 1972 Feb;53(1):44–49. [PMC free article] [PubMed] [Google Scholar]
  5. Duval F., Lavarde V. Contribution à l'étude pharmacologique in vitro du fluconazole. Mise au point d'un antifongigramme. Pathol Biol (Paris) 1993 May;41(5):469–473. [PubMed] [Google Scholar]
  6. Fields B. T., Jr, Bates J. H., Abernathy R. S. Amphotericin B serum concentrations during therapy. Appl Microbiol. 1970 Jun;19(6):955–959. doi: 10.1128/am.19.6.955-959.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Filler S. G., Crislip M. A., Mayer C. L., Edwards J. E., Jr Comparison of fluconazole and amphotericin B for treatment of disseminated candidiasis and endophthalmitis in rabbits. Antimicrob Agents Chemother. 1991 Feb;35(2):288–292. doi: 10.1128/aac.35.2.288. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Longman L. P., Hibbert S. A., Martin M. V. Efficacy of fluconazole in prophylaxis and treatment of experimental Candida endocarditis. Rev Infect Dis. 1990 Mar-Apr;12 (Suppl 3):S294–S298. doi: 10.1093/clinids/12.supplement_3.s294. [DOI] [PubMed] [Google Scholar]
  9. Robinson P. A., Knirsch A. K., Joseph J. A. Fluconazole for life-threatening fungal infections in patients who cannot be treated with conventional antifungal agents. Rev Infect Dis. 1990 Mar-Apr;12 (Suppl 3):S349–S363. doi: 10.1093/clinids/12.supplement_3.s349. [DOI] [PubMed] [Google Scholar]
  10. Rubinstein E., Noriega E. R., Simberkoff M. S., Rahal J. J., Jr Tissue penetration of amphotericin B in Candida endocarditis. Chest. 1974 Oct;66(4):376–377. doi: 10.1378/chest.66.4.376. [DOI] [PubMed] [Google Scholar]
  11. Saag M. S., Dismukes W. E. Azole antifungal agents: emphasis on new triazoles. Antimicrob Agents Chemother. 1988 Jan;32(1):1–8. doi: 10.1128/aac.32.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Sande M. A., Bowman C. R., Calderone R. A. Experimental Candida albicans endocarditis: characterization of the disease and response to therapy. Infect Immun. 1977 Jul;17(1):140–147. doi: 10.1128/iai.17.1.140-147.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Thaler F., Bernard B., Tod M., Jedynak C. P., Petitjean O., Derome P., Loirat P. Fluconazole penetration in cerebral parenchyma in humans at steady state. Antimicrob Agents Chemother. 1995 May;39(5):1154–1156. doi: 10.1128/aac.39.5.1154. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Wallace J. E., Harris S. C., Gallegos J., Foulds G., Chen T. J., Rinaldi M. G. Assay of fluconazole by high-performance liquid chromatography with a mixed-phase column. Antimicrob Agents Chemother. 1992 Mar;36(3):603–606. doi: 10.1128/aac.36.3.603. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Walsh T. J., Aoki S., Mechinaud F., Bacher J., Lee J., Rubin M., Pizzo P. A. Effects of preventive, early, and late antifungal chemotherapy with fluconazole in different granulocytopenic models of experimental disseminated candidiasis. J Infect Dis. 1990 Apr;161(4):755–760. doi: 10.1093/infdis/161.4.755. [DOI] [PubMed] [Google Scholar]
  16. Witt M. D., Bayer A. S. Comparison of fluconazole and amphotericin B for prevention and treatment of experimental Candida endocarditis. Antimicrob Agents Chemother. 1991 Dec;35(12):2481–2485. doi: 10.1128/aac.35.12.2481. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Witt M. D., Imhoff T., Li C., Bayer A. S. Comparison of fluconazole and amphotericin B for treatment of experimental Candida endocarditis caused by non-C. albicans strains. Antimicrob Agents Chemother. 1993 Sep;37(9):2030–2032. doi: 10.1128/aac.37.9.2030. [DOI] [PMC free article] [PubMed] [Google Scholar]

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