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Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1996 Jan;40(1):267–270. doi: 10.1128/aac.40.1.267

Simple in vitro translation assay to analyze inhibitors of rhinovirus proteases.

B A Heinz 1, J Tang 1, J M Labus 1, F W Chadwell 1, S W Kaldor 1, M Hammond 1
PMCID: PMC163099  PMID: 8787922

Abstract

We have developed a simple in vitro translation method to analyze compounds that inhibit the rhinovirus 3C protease in peptide substrate assays but demonstrate no antiviral activity. This complementary assay, which provides both qualitative and quantitative results, detects the inhibition of the 3CD protease in the native polyprotein form.

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Selected References

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