Abstract
All the survivors of a series of 88 patients with Henoch-Schönlein nephritis were examined after a follow-up of six and a half to 21 years (mean 9-9). Sixty-one patients had no demonstrable abnormality; six had minor urinary abnormalities; five had hypertension without urinary abnormally or renal dysfunction; four had heavy proteinuria; eight were in chronic renal failure, three of whom were on regular dialysis; and four patients had died within 25 months of onset. Neither corticosteroids nor immunosuppressive drugs alone or in combination appeared to influence the outcome. A clinical presentation with a combination of acute nephritis and a nephrotic syndrome and a high proportion of crescents in renal biopsy specimens was associated with a poor outcome. Neither the clinical presentation nor the renal morphology were, however, precise determinants of outcome. Outcome was not related to age, associated streptococcal infection, or recurrences of the rash. The clinical state two years after presentation was compared with the state six and a half years or more after presentation in 76 patients. The clinical state had changed in 32 patients, in 17 of whom it had deteriorated. It was not possible to identify with any certainty the patients who would deteriorate (or improve). Patients who have had Henoch-Schönlein nephritis should be followed up for at least five years.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brown C. B., Wilson D., Turner D., Cameron J. S., Ogg C. S., Chantler C., Gill D. Combined immunosuppression and anticoagulation in rapidly progressive glomerulonephritis. Lancet. 1974 Nov 16;2(7890):1166–1172. doi: 10.1016/s0140-6736(74)90810-1. [DOI] [PubMed] [Google Scholar]
- Chantler C., Barratt T. M. Estimation of glomerular filtration rate from plasma clearance of 51-chromium edetic acid. Arch Dis Child. 1972 Aug;47(254):613–617. doi: 10.1136/adc.47.254.613. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kincaid-Smith P., Saker B. M., Fairley K. F. Anticoagulants in "irreversible" acute renal failure. Lancet. 1968 Dec 28;2(7583):1360–1363. doi: 10.1016/s0140-6736(68)92671-8. [DOI] [PubMed] [Google Scholar]
- Meadow S. R., Glasgow E. F., White R. H., Moncrieff M. W., Cameron J. S., Ogg C. S. Schönlein-Henoch nephritis. Q J Med. 1972 Jul;41(163):241–258. [PubMed] [Google Scholar]