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. 1996 Mar;40(3):792–794. doi: 10.1128/aac.40.3.792

Inhibition of duck hepatitis B virus replication by 2',3'-dideoxy-3'-fluoroguanosine in vitro and in vivo.

P Hafkemeyer 1, A Keppler-Hafkemeyer 1, M A al Haya 1, M von Janta-Lipinski 1, E Matthes 1, C Lehmann 1, W B Offensperger 1, S Offensperger 1, W Gerok 1, H E Blum 1
PMCID: PMC163202  PMID: 8851615

Abstract

The antiviral activity of 2',3'-dideoxy-3'-fluoroguanosine (FdG) or its triphosphate was evaluated in the duck hepatitis B virus (DHBV) system in vitro and in vivo. In primary DHBV-infected hepatocytes FdG results in a dose-dependent inhibition of viral replication with a nearly complete inhibition at a concentration of 1 microM. Also in vivo, FdG treatment of DHBV-infected ducklings reduces DHBV DNA replication by more than 90%. These data demonstrate that FdG is a strong inhibitor of DHBV replication in vitro and in vivo.

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Selected References

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