Abstract
An open randomized comparison of 2 days (Ofx2) versus 3 days (Ofx3) of oral ofloxacin treatment (15 mg/kg/day) was conducted with Vietnamese children between 1 and 15 years of age with suspected typhoid fever. Of 108 children enrolled, 100 were blood culture positive for Salmonella typhi, and 86% of the isolates were multidrug resistant. There were no significant adverse effects. The therapeutic responses were similar in both groups, with mean (+/- standard deviation) fever clearances of 107 +/- 60 h in the Ofx3 group and 100 +/- 64 h in the Ofx2 group (P > 0.2). There were six "clinical" failures in the Ofx2 group and two clinical failures in the Ofx3 group (P > 0.2), in which fever and symptoms persisted for more than 1 week after the start of treatment, but only one of these was culture positive (Ofx3). There was one suspected relapse, and one carrier was identified. Short courses of ofloxacin are simple, inexpensive, safe, and effective for the treatment of uncomplicated multidrug-resistant typhoid fever.
Full Text
The Full Text of this article is available as a PDF (174.6 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Butler T., Linh N. N., Arnold K., Pollack M. Chloramphenicol-resistant typhoid fever in Vietnam associated with R factor. Lancet. 1973 Nov 3;302(7836):983–985. doi: 10.1016/s0140-6736(73)91086-6. [DOI] [PubMed] [Google Scholar]
- Dutta P., Rasaily R., Saha M. R., Mitra U., Bhattacharya S. K., Bhattacharya M. K., Lahiri M. Ciprofloxacin for treatment of severe typhoid fever in children. Antimicrob Agents Chemother. 1993 May;37(5):1197–1199. doi: 10.1128/aac.37.5.1197. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mourad A. S., Metwally M., el Deen A. N., Threlfall E. J., Rowe B., Mapes T., Hedstrom R., Bourgeois A. L., Murphy J. R. Multiple-drug-resistant Salmonella typhi. Clin Infect Dis. 1993 Jul;17(1):135–136. doi: 10.1093/clinids/17.1.135. [DOI] [PubMed] [Google Scholar]
- Rao P. S., Rajashekar V., Varghese G. K., Shivananda P. G. Emergence of multidrug-resistant Salmonella typhi in rural southern India. Am J Trop Med Hyg. 1993 Jan;48(1):108–111. doi: 10.4269/ajtmh.1993.48.108. [DOI] [PubMed] [Google Scholar]
- Smith M. D., Duong N. M., Hoa N. T., Wain J., Ha H. D., Diep T. S., Day N. P., Hien T. T., White N. J. Comparison of ofloxacin and ceftriaxone for short-course treatment of enteric fever. Antimicrob Agents Chemother. 1994 Aug;38(8):1716–1720. doi: 10.1128/aac.38.8.1716. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stanley P. J., Flegg P. J., Mandal B. K., Geddes A. M. Open study of ciprofloxacin in enteric fever. J Antimicrob Chemother. 1989 May;23(5):789–791. doi: 10.1093/jac/23.5.789. [DOI] [PubMed] [Google Scholar]
- Tran T. H., Bethell D. B., Nguyen T. T., Wain J., To S. D., Le T. P., Bui M. C., Nguyen M. D., Pham T. T., Walsh A. L. Short course of ofloxacin for treatment of multidrug-resistant typhoid. Clin Infect Dis. 1995 Apr;20(4):917–923. [PubMed] [Google Scholar]
- Tran T. H., Nguyen M. D., Huynh D. H., Nguyen T. T., To S. D., Le T. P., Arnold K. A randomized comparative study of fleroxacin and ceftriaxone in enteric fever. Trans R Soc Trop Med Hyg. 1994 Jul-Aug;88(4):464–465. doi: 10.1016/0035-9203(94)90435-9. [DOI] [PubMed] [Google Scholar]
- Uwaydah A. K., al Soub H., Matar I. Randomized prospective study comparing two dosage regimens of ciprofloxacin for the treatment of typhoid fever. J Antimicrob Chemother. 1992 Nov;30(5):707–711. doi: 10.1093/jac/30.5.707. [DOI] [PubMed] [Google Scholar]
- Wallace M. R., Yousif A. A., Mahroos G. A., Mapes T., Threlfall E. J., Rowe B., Hyams K. C. Ciprofloxacin versus ceftriaxone in the treatment of multiresistant typhoid fever. Eur J Clin Microbiol Infect Dis. 1993 Dec;12(12):907–910. doi: 10.1007/BF01992163. [DOI] [PubMed] [Google Scholar]
- Wang F., Gu X. J., Zhang M. F., Tai T. Y. Treatment of typhoid fever with ofloxacin. J Antimicrob Chemother. 1989 May;23(5):785–788. doi: 10.1093/jac/23.5.785. [DOI] [PubMed] [Google Scholar]
- el-Sherbini A. An outbreak of typhoid fever resistant to chloramphenicol and other drugs in Gharbeya Governorate in Egypt. J Trop Pediatr. 1992 Dec;38(6):331–334. doi: 10.1093/tropej/38.6.331. [DOI] [PubMed] [Google Scholar]