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. 1996 Apr;40(4):1009–1013. doi: 10.1128/aac.40.4.1009

Mutations in gyrA gene of quinolone-resistant Salmonella serotypes isolated from humans and animals.

D J Griggs 1, K Gensberg 1, L J Piddock 1
PMCID: PMC163248  PMID: 8849216

Abstract

The quinolone resistance-determining regions (QRDRs) of the gyrA genes of quinolone-resistant clinical and veterinary salmonella isolates were sequenced. Substitutions analogous to a substitution of a Ser to a Phe at position 83 (Ser83-->Phe) and Asp87-->Gly or Tyr in Escherichia coli were found, as was a single novel mutation outside of the QRDR resulting in Ala119-->Glu. The data suggest that gyrA mutations are associated with quinolone resistance in veterinary and clinical salmonella isolates and that the limits of the QRDR may require revision.

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Selected References

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