Abstract
Two oxazolidinones and ceftriaxone, imipenem, rifampin, and vancomycin were tested against 162 penicillin-intermediate and 68 penicillin-resistant strains of pneumococci. U-100592 is two- to fourfold more active than U-100766 against penicillin-resistant pneumococci. The MICs of U-100592 at which 90% of the isolates were inhibited were 0.25 and 0.5 microgram/ml for penicillin-intermediate and -resistant strains, respectively, and 0.5 microgram/ml for ceftriaxone-susceptible, -intermediate, and -resistant strains. U-100592 MICs for 7 of 230 strains (2 from blood, 3 from middle-ear fluid, and 2 from the upper respiratory tract) were 1 microgram/ml.
Full Text
The Full Text of this article is available as a PDF (156.2 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Block S. L., Harrison C. J., Hedrick J. A., Tyler R. D., Smith R. A., Keegan E., Chartrand S. A. Penicillin-resistant Streptococcus pneumoniae in acute otitis media: risk factors, susceptibility patterns and antimicrobial management. Pediatr Infect Dis J. 1995 Sep;14(9):751–759. doi: 10.1097/00006454-199509000-00005. [DOI] [PubMed] [Google Scholar]
- Duchin J. S., Breiman R. F., Diamond A., Lipman H. B., Block S. L., Hedrick J. A., Finger R., Elliott J. A. High prevalence of multidrug-resistant Streptococcus pneumoniae among children in a rural Kentucky community. Pediatr Infect Dis J. 1995 Sep;14(9):745–750. doi: 10.1097/00006454-199509000-00004. [DOI] [PubMed] [Google Scholar]
- Friedland I. R. Comparison of the response to antimicrobial therapy of penicillin-resistant and penicillin-susceptible pneumococcal disease. Pediatr Infect Dis J. 1995 Oct;14(10):885–890. doi: 10.1097/00006454-199510000-00013. [DOI] [PubMed] [Google Scholar]
- Friedland I. R., Istre G. R. Management of penicillin-resistant pneumococcal infections. Pediatr Infect Dis J. 1992 Jun;11(6):433–435. doi: 10.1097/00006454-199206000-00002. [DOI] [PubMed] [Google Scholar]
- Friedland I. R., Shelton S., Paris M., Rinderknecht S., Ehrett S., Krisher K., McCracken G. H., Jr Dilemmas in diagnosis and management of cephalosporin-resistant Streptococcus pneumoniae meningitis. Pediatr Infect Dis J. 1993 Mar;12(3):196–200. doi: 10.1097/00006454-199303000-00004. [DOI] [PubMed] [Google Scholar]
- Klugman K. P. Management of antibiotic-resistant pneumococcal infections. J Antimicrob Chemother. 1994 Aug;34(2):191–193. doi: 10.1093/jac/34.2.191. [DOI] [PubMed] [Google Scholar]
- Klugman K. P. Pneumococcal resistance to antibiotics. Clin Microbiol Rev. 1990 Apr;3(2):171–196. doi: 10.1128/cmr.3.2.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McCracken G. H., Jr Emergence of resistant Streptococcus pneumoniae: a problem in pediatrics. Pediatr Infect Dis J. 1995 May;14(5):424–428. doi: 10.1097/00006454-199505001-00004. [DOI] [PubMed] [Google Scholar]
- Tan T. Q., Mason E. O., Jr, Kaplan S. L. Systemic infections due to Streptococcus pneumoniae relatively resistant to penicillin in a children's hospital: clinical management and outcome. Pediatrics. 1992 Dec;90(6):928–933. [PubMed] [Google Scholar]