Abstract
Nitric oxide (NO) generated by two NO donors (sodium nitroprusside or S-nitroso-L-glutathione) was shown to exert a dose-dependent inhibition of encephalomyocarditis virus growth in L-929 cells. This activity was not due to the cytotoxic or direct virucidal effects of NO donors. L-929 cells were shown to produce NO endogenously, but this low level of production did not counter encephalomyocarditis virus replication.
Full Text
The Full Text of this article is available as a PDF (182.3 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bi Z., Reiss C. S. Inhibition of vesicular stomatitis virus infection by nitric oxide. J Virol. 1995 Apr;69(4):2208–2213. doi: 10.1128/jvi.69.4.2208-2213.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Croen K. D. Evidence for antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication. J Clin Invest. 1993 Jun;91(6):2446–2452. doi: 10.1172/JCI116479. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cui S., Reichner J. S., Mateo R. B., Albina J. E. Activated murine macrophages induce apoptosis in tumor cells through nitric oxide-dependent or -independent mechanisms. Cancer Res. 1994 May 1;54(9):2462–2467. [PubMed] [Google Scholar]
- Feelisch M., Noack E. Nitric oxide (NO) formation from nitrovasodilators occurs independently of hemoglobin or non-heme iron. Eur J Pharmacol. 1987 Oct 27;142(3):465–469. doi: 10.1016/0014-2999(87)90090-2. [DOI] [PubMed] [Google Scholar]
- Fleury C., Cotte J., Quero A. M. Evaluation de la cytotoxicité d'un antiseptique par une microméthode photométrique. Pathol Biol (Paris) 1984 Jun;32(5 Pt 2):628–630. [PubMed] [Google Scholar]
- Guillemard E., Geniteau-Legendre M., Mabboux B., Poilane I., Kergot R., Lemaire G., Petit J. F., Labarre C., Quero A. M. Antiviral action of trehalose dimycolate against EMC virus: role of macrophages and interferon alpha/beta. Antiviral Res. 1993 Oct;22(2-3):201–213. doi: 10.1016/0166-3542(93)90096-2. [DOI] [PubMed] [Google Scholar]
- Harris N., Buller R. M., Karupiah G. Gamma interferon-induced, nitric oxide-mediated inhibition of vaccinia virus replication. J Virol. 1995 Feb;69(2):910–915. doi: 10.1128/jvi.69.2.910-915.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Karupiah G., Harris N. Inhibition of viral replication by nitric oxide and its reversal by ferrous sulfate and tricarboxylic acid cycle metabolites. J Exp Med. 1995 Jun 1;181(6):2171–2179. doi: 10.1084/jem.181.6.2171. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Karupiah G., Xie Q. W., Buller R. M., Nathan C., Duarte C., MacMicking J. D. Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase. Science. 1993 Sep 10;261(5127):1445–1448. doi: 10.1126/science.7690156. [DOI] [PubMed] [Google Scholar]
- Keller R., Gehri R., Keist R. Macrophage response to viruses, protozoa, and fungi: secretory and cellular activities induced in resting unprimed bone marrow-derived mononuclear phagocytes. Cell Immunol. 1994 Dec;159(2):323–330. doi: 10.1006/cimm.1994.1318. [DOI] [PubMed] [Google Scholar]
- Kowaluk E. A., Fung H. L. Spontaneous liberation of nitric oxide cannot account for in vitro vascular relaxation by S-nitrosothiols. J Pharmacol Exp Ther. 1990 Dec;255(3):1256–1264. [PubMed] [Google Scholar]
- Lancaster J. R., Jr, Werner-Felmayer G., Wachter H. Coinduction of nitric oxide synthesis and intracellular nonheme iron-nitrosyl complexes in murine cytokine-treated fibroblasts. Free Radic Biol Med. 1994 Jun;16(6):869–870. doi: 10.1016/0891-5849(94)90206-2. [DOI] [PubMed] [Google Scholar]
- Nathan C., Xie Q. W. Nitric oxide synthases: roles, tolls, and controls. Cell. 1994 Sep 23;78(6):915–918. doi: 10.1016/0092-8674(94)90266-6. [DOI] [PubMed] [Google Scholar]