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. 1996 Apr;40(4):1060–1062. doi: 10.1128/aac.40.4.1060

GyrB mutations in Staphylococcus aureus strains resistant to cyclothialidine, coumermycin, and novobiocin.

M Stieger 1, P Angehrn 1, B Wohlgensinger 1, H Gmünder 1
PMCID: PMC163264  PMID: 8849232

Abstract

The sequence of the gyrase B subunit gene from Staphylococcus aureus strains resistant to the gyrase B subunit inhibitors cyclothialidine, coumermycin, and novobiocin has been determined. The residues altered in the resistant gyrase B subunits map to the ATP-binding region, suggesting that the drugs inhibit ATP binding and hydrolysis. The pattern of cross-resistances indicates that the detailed binding mode of the compounds differs.

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Selected References

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