Abstract
A one-hour D-xylose absorption test was performed on 18 children with acute lymphoblastic leukaemia. Xylose absorption was normal in children who had not received methotrexate, but there was a significant degree of malabsorption in those who had taken methotrexate within the previous seven days. There was a progressive and significant increase in malabsorption related to the cumulative dose of methotrexate. These findings provide further evidence that regular methotrexate treatment every seven days is more toxic than if it is more widely spaced. The spacing of treatment is currently under investigation.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Holland J. F., Glidewell O. Oncologists' reply: survival expectancy in acute lymphocytic leukemia. N Engl J Med. 1972 Oct 12;287(15):769–777. doi: 10.1056/NEJM197210122871512. [DOI] [PubMed] [Google Scholar]
- MacLennan I. C., Kay H. E., Festenstein M., Smith P. G. Analysis of treatment in childhood leukaemia. II. Timing and the toxicity of combined 6-mercaptopurine and methotrexate maintenance therapy. Br J Haematol. 1976 Jun;33(2):179–188. doi: 10.1111/j.1365-2141.1976.tb03529.x. [DOI] [PubMed] [Google Scholar]
- Mauer A. M., Simone J. V. The current status of the treatment of childhood acute lymphoblastic leukemia. Cancer Treat Rev. 1976 Mar;3(1):17–41. doi: 10.1016/s0305-7372(76)80015-1. [DOI] [PubMed] [Google Scholar]
- Robinson J. W., Antonioli J. A., Vannotti A. The effect of oral methotrexate on the rat intestine. Biochem Pharmacol. 1966 Oct;15(10):1479–1489. doi: 10.1016/0006-2952(66)90193-6. [DOI] [PubMed] [Google Scholar]
- Rolles C. J., Nutter S., Kendall M. J., Anderson C. M. One-hour blood-xylose screening-test for coeliac disease in infants and young children. Lancet. 1973 Nov 10;2(7837):1043–1045. doi: 10.1016/s0140-6736(73)92656-1. [DOI] [PubMed] [Google Scholar]
- SMALL M. D., CAVANAGH R. L., GOTTLIEB L., COLON P. L., ZAMCHECK N. The effect of aminopterin on the absorption of xylose from the rat small intestine. Am J Dig Dis. 1959 Sep;4:700–705. doi: 10.1007/BF02232175. [DOI] [PubMed] [Google Scholar]
- Shalet S. M., Beardwell C. G., Jones P. H., Pearson D. Growth hormone deficiency after treatment of acute leukaemia in children. Arch Dis Child. 1976 Jul;51(7):489–493. doi: 10.1136/adc.51.7.489. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Venho V. M. Effect of methotrexate on drug absorption from the rat small intestine in situ and in vitro. Acta Pharmacol Toxicol (Copenh) 1976 May;38(5):450–464. doi: 10.1111/j.1600-0773.1976.tb03141.x. [DOI] [PubMed] [Google Scholar]