Skip to main content
NCBI home page
British Medical Journal logoLink to British Medical Journal
. 1974 Jan 12;1(5897):52–55. doi: 10.1136/bmj.1.5897.52

Hyponatraemia Syndrome in Acute Myeloid Leukaemia

M A Mir, I W Delamore
PMCID: PMC1632902  PMID: 4521414

Abstract

Hyponatraemia was observed in 11 out of 14 consecutive patients with acute myeloid leukaemia and its variants. Metabolic studies on these patients revealed an early increase in the urinary sodium excretion, negative free water clearance, and urine osmolality inappropriately higher than that of the serum. It is postulated that this syndrome is caused by a substance released from the primitive cells of the abnormal myeloid series.

Full text

PDF
52

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bartter F. C., Schwartz W. B. The syndrome of inappropriate secretion of antidiuretic hormone. Am J Med. 1967 May;42(5):790–806. doi: 10.1016/0002-9343(67)90096-4. [DOI] [PubMed] [Google Scholar]
  2. FESSAS P., WINTROBE M. M., THOMPSON R. B., CARTWRIGHT G. E. Treatment of acute leukemia with cortisone and corticotropin. AMA Arch Intern Med. 1954 Sep;94(3):384–401. doi: 10.1001/archinte.1954.00250030054007. [DOI] [PubMed] [Google Scholar]
  3. Fine D., Shedrovilzky H. Hyponatremia due to chlorpropamide. A syndrome resembling inappropriate secretion of antidiuretic hormone. Ann Intern Med. 1970 Jan;72(1):83–87. doi: 10.7326/0003-4819-72-1-83. [DOI] [PubMed] [Google Scholar]
  4. Kaye M. An investigation into the cause of hyponatremia in the syndrome of inappropriate secretion of antidiuretic hormone. Am J Med. 1966 Dec;41(6):910–926. doi: 10.1016/0002-9343(66)90049-0. [DOI] [PubMed] [Google Scholar]
  5. MATTINGLY D., DENNIS P. M., PEARSON J., COPE C. L. RAPID SCREENING TEST FOR ADRENAL CORTICAL FUNCTION. Lancet. 1964 Nov 14;2(7368):1046–1049. doi: 10.1016/s0140-6736(64)90994-8. [DOI] [PubMed] [Google Scholar]
  6. Osserman E. F., Lawlor D. P. Serum and urinary lysozyme (muramidase) in monocytic and monomyelocytic leukemia. J Exp Med. 1966 Nov 1;124(5):921–952. doi: 10.1084/jem.124.5.921. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. SCHWARTZ W. B., BENNETT W., CURELOP S., BARTTER F. C. A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. Am J Med. 1957 Oct;23(4):529–542. doi: 10.1016/0002-9343(57)90224-3. [DOI] [PubMed] [Google Scholar]
  8. Sawyer R. B., Spencer J. R., Dudzinski P. J., Enis J. E. Hypernatremia with pharmacologic doses of steroids. Am J Surg. 1967 Nov;114(5):691–694. doi: 10.1016/0002-9610(67)90130-4. [DOI] [PubMed] [Google Scholar]
  9. Simons K., Weber T. The vitamin B12-binding protein in human leukocytes. Biochim Biophys Acta. 1966 Mar 28;117(1):201–208. doi: 10.1016/0304-4165(66)90167-x. [DOI] [PubMed] [Google Scholar]
  10. Weissman P. N., Shenkman L., Gregerman R. I. Chlorpropamide hyponatremia: drug-induced inappropriate antidiuretic-hormone activity. N Engl J Med. 1971 Jan 14;284(2):65–71. doi: 10.1056/NEJM197101142840202. [DOI] [PubMed] [Google Scholar]

Articles from British Medical Journal are provided here courtesy of BMJ Publishing Group

RESOURCES