Abstract
A metabolic defect has been observed in extracts of lipomata in which citrate fails to inhibit the conversion of glucose-6-phosphate to glyceride-glycerol. Phospho-fructokinase extracted from lipomata was less sensitive to inhibition by citrate than the enzyme of normal adipose tissue. However, maximal rates of lipogenesis (from glucose or palmitate) and lipolysis (stimulated with isoprenaline) in lipomata were similar to those of normal adipose tissue. This work suggests that loss of negative feedback control of regulatory enzymes may be an early feature in the development of neoplasia.
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- Brown B. L., Albano J. D., Ekins R. P., Sgherzi A. M. A simple and sensitive saturation assay method for the measurement of adenosine 3':5'-cyclic monophosphate. Biochem J. 1971 Feb;121(3):561–562. doi: 10.1042/bj1210561. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GARLAND P. B., RANDLE P. J. A rapid enzymatic assay for glycerol. Nature. 1962 Dec 8;196:987–988. doi: 10.1038/196987a0. [DOI] [PubMed] [Google Scholar]
- Galton D. J., Wilson J. P., Kissebah A. H. The effect of adult diabetes on glucose utilization and esterification of palmitate by human adipose tissue. Eur J Clin Invest. 1971 Sep;1(6):399–404. doi: 10.1111/j.1365-2362.1971.tb00548.x. [DOI] [PubMed] [Google Scholar]
- Galton D. J., Wilson J. P. Lipogenesis in homogenates of human adipose tissue. Clin Sci. 1970 Jun;38(6):649–660. doi: 10.1042/cs0380649. [DOI] [PubMed] [Google Scholar]
- SIPERSTEIN M. D., FAGAN V. M. DELETION OF THE CHOLESTEROL-NEGATIVE FEEDBACK SYSTEM IN LIVER TUMORS. Cancer Res. 1964 Aug;24:1108–1115. [PubMed] [Google Scholar]
- Siperstein M. D., Fagan V. M., Morris H. P. Further studies on the deletion of the cholesterol feedback system in hepatomas. Cancer Res. 1966 Jan;26(1):7–11. [PubMed] [Google Scholar]