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. 1996 May;40(5):1289–1293. doi: 10.1128/aac.40.5.1289

Differences in the resistant variants of Enterobacter cloacae selected by extended-spectrum cephalosporins.

J C Fung-Tomc 1, E Gradelski 1, E Huczko 1, T J Dougherty 1, R E Kessler 1, D P Bonner 1
PMCID: PMC163312  PMID: 8723487

Abstract

The rates of development of resistance to ceftriaxone, ceftazidime, cefepime, and cefpirome in 10 strains of Enterobacter cloacae were determined by daily transfer for 7 days to fresh medium containing twofold serial dilutions of the antibiotics. Development of resistance to ceftriaxone was the most rapid; this was followed by ceftazidime, cefpirome, and cefepime. Resistant variants selected by ceftriaxone and ceftazidime were cross-resistant and produced very high levels of beta-lactamase. On the other hand, resistant variants selected by cefepime and cefpirome often had moderately high levels of beta-lactamase and diminished levels of the 39- to 40-kDa porin protein.

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Selected References

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