Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1996 May;40(5):1311–1313. doi: 10.1128/aac.40.5.1311

Concentrations of ceftriaxone (1,000 milligrams intravenously) in abdominal tissues during open prostatectomy.

C Martin 1, X Viviand 1, A Cottin 1, V Savelli 1, C Brousse 1, E Ragni 1, C Richaud 1, M N Mallet 1
PMCID: PMC163318  PMID: 8723493

Abstract

Ceftriaxone concentrations in abdominal tissues were evaluated at different stages of open prostatectomy. Ceftriaxone was administered as antibiotic prophylaxis, and 15 consecutive patients were given a single dose of ceftriaxone (1,000 mg intravenously in 1 min) 30 min before surgery. Ceftriaxone concentrations in tissue were determined at three stages of the surgical procedure; upon the opening of the abdominal cavity, during the prostatectomy, and upon the closure of the abdominal cavity. Samples of the following tissues or sample were assayed: epiploic and abdominal-wall fat; Retzius' space, bladder, and prostate tissue; and urine. During the different stages of the surgical procedure, for all patients, and in the different tested tissues, ceftriaxone concentrations greater than or equal to the cutoff point (4 micrograms/g of tissue) were measured. The highest concentrations were obtained in the bladder (43 +/- 18 micrograms/g) and in the prostate (35 +/- 18 micrograms/g). In fatty tissues, concentrations were between 13 +/- 5 and 22 +/- 8 micrograms/g. All patients (15 of 15) had ceftriaxone levels in tissue greater than the MICs for the potential pathogens (Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis). In conclusion, during open prostatectomy and after the use of a single dose of ceftriaxone (1,000 mg), high antibiotic levels were obtained throughout the surgical procedure in the tissues potentially involved in postoperative infection.

Full Text

The Full Text of this article is available as a PDF (172.8 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adam D., Naber K. G. Concentrations of ceftriaxone in prostate adenoma tissue. Chemotherapy. 1984;30(1):1–6. doi: 10.1159/000238237. [DOI] [PubMed] [Google Scholar]
  2. Amin M. Antibacterial prophylaxis in urology: a review. Am J Med. 1992 Apr 6;92(4A):114S–117S. doi: 10.1016/0002-9343(92)90321-2. [DOI] [PubMed] [Google Scholar]
  3. Bergamini T. M., Polk H. C., Jr The importance of tissue antibiotic activity in the prevention of operative wound infection. J Antimicrob Chemother. 1989 Mar;23(3):301–313. doi: 10.1093/jac/23.3.301. [DOI] [PubMed] [Google Scholar]
  4. Brogden R. N., Ward A. Ceftriaxone. A reappraisal of its antibacterial activity and pharmacokinetic properties, and an update on its therapeutic use with particular reference to once-daily administration. Drugs. 1988 Jun;35(6):604–645. doi: 10.2165/00003495-198835060-00002. [DOI] [PubMed] [Google Scholar]
  5. Burke J. F. The effective period of preventive antibiotic action in experimental incisions and dermal lesions. Surgery. 1961 Jul;50:161–168. [PubMed] [Google Scholar]
  6. Classen D. C., Evans R. S., Pestotnik S. L., Horn S. D., Menlove R. L., Burke J. P. The timing of prophylactic administration of antibiotics and the risk of surgical-wound infection. N Engl J Med. 1992 Jan 30;326(5):281–286. doi: 10.1056/NEJM199201303260501. [DOI] [PubMed] [Google Scholar]
  7. Conte J. E., Jr, Cohen S. N., Roe B. B., Elashoff R. M. Antibiotic prophylaxis and cardiac surgery. A prospective double-blind comparison of single-dose versus multiple-dose regimens. Ann Intern Med. 1972 Jun;76(6):943–949. doi: 10.7326/0003-4819-76-6-943. [DOI] [PubMed] [Google Scholar]
  8. Finkelstein L. H., Arsht D. B., Manfrey S. J., Childs S. Ceftriaxone in the prevention of postoperative infection in patients undergoing transurethral resection of the prostate. Am J Surg. 1984 Oct 19;148(4A):19–21. [PubMed] [Google Scholar]
  9. Kaiser A. B. Antimicrobial prophylaxis in surgery. N Engl J Med. 1986 Oct 30;315(18):1129–1138. doi: 10.1056/NEJM198610303151805. [DOI] [PubMed] [Google Scholar]
  10. Knapp C. C., Sierra-Madero J., Washington J. A. Antibacterial activities of cefpodoxime, cefixime, and ceftriaxone. Antimicrob Agents Chemother. 1988 Dec;32(12):1896–1898. doi: 10.1128/aac.32.12.1896. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Larsen E. H., Gasser T. C., Madsen P. O. Antimicrobial prophylaxis in urologic surgery. Urol Clin North Am. 1986 Nov;13(4):591–604. [PubMed] [Google Scholar]
  12. Martin C. Antimicrobial prophylaxis in surgery: general concepts and clinical guidelines. French Study Group on Antimicrobial Prophylaxis in Surgery, French Society of Anesthesia and Intensive Care. Infect Control Hosp Epidemiol. 1994 Jul;15(7):463–471. doi: 10.1086/646952. [DOI] [PubMed] [Google Scholar]
  13. Martin C., Ragni J., Lokiec F., Guillen J. C., Auge A., Pecking M., Gouin F. Pharmacokinetics and tissue penetration of a single dose of ceftriaxone (1,000 milligrams intravenously) for antibiotic prophylaxis in thoracic surgery. Antimicrob Agents Chemother. 1992 Dec;36(12):2804–2807. doi: 10.1128/aac.36.12.2804. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Mutch D., Richards G., Brown R. A., Mulder D. S. Bioactive antibiotic levels in the human aorta. Surgery. 1982 Dec;92(6):1068–1071. [PubMed] [Google Scholar]
  15. Pitkin D. H., Sachs C., Zajac I., Actor P. Distribution of sodium cefazolin in serum, muscle, bone marrow, and bone of normal rabbits. Antimicrob Agents Chemother. 1977 Apr;11(4):760–762. doi: 10.1128/aac.11.4.760. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Raz R., Almog D., Elhanan G., Shental J. The use of ceftriaxone in the prevention of urinary tract infection in patients undergoing transurethral resection of the prostate (TUR-P). Infection. 1994 Sep-Oct;22(5):347–349. doi: 10.1007/BF01715544. [DOI] [PubMed] [Google Scholar]
  17. Stone H. H. Basic principles in the use of prophylactic antibiotics. J Antimicrob Chemother. 1984 Sep;14 (Suppl B):33–37. doi: 10.1093/jac/14.suppl_b.33. [DOI] [PubMed] [Google Scholar]
  18. Washington J. A., 2nd The effects and significance of subminimal inhibitory concentrations of antibiotics. Rev Infect Dis. 1979 Sep-Oct;1(5):781–786. doi: 10.1093/clinids/1.5.781. [DOI] [PubMed] [Google Scholar]
  19. del Rio G., Dalet F., Chechile G. Antimicrobial prophylaxis in urologic surgery: does it give some benefit? Eur Urol. 1993;24(3):305–312. doi: 10.1159/000474318. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES