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. 1974 Mar 16;1(5906):488–491. doi: 10.1136/bmj.1.5906.488

Diurnal Variation in Response to Intravenous Glucose*

Margaret J Whichelow, R A Sturge, H Keen, R J Jarrett, L Stimmler, Susan Grainger
PMCID: PMC1633499  PMID: 4817160

Abstract

Intravenous glucose tolerance tests (25 g) were performed in the morning and afternoon on 13 apparently normal persons. The individual K values (rate of decline of blood sugar) were all higher in the morning tests, and the mean values were significantly higher in the morning. Fasting blood sugar levels were slightly lower in the afternoon. There was no difference between the fasting morning and afternoon plasma insulin levels, but the levels after glucose were lower in the afternoon. Growth hormone levels were low at all times in non-apprehensive subjects and unaffected by glucose. The results suggest that the impaired afternoon intravenous glucose tolerance, like oral glucose tolerance, is associated with impaired insulin release and insulin resistance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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