Abstract
Omeprazole and lansoprazole are proton pump inhibitors that have shown activity against Helicobacter pylori and other Helicobacter species when tested by agar dilution. Lansoprazole was more active against H. pylori than was omeprazole, and the activity was independent of urease production. Disk susceptibility tests and agar dilution MIC determinations were performed to investigate the effects of incubation under different sets of atmospheric conditions on H. pylori inhibition. Oxygen concentration was found to influence proton pump inhibitor activity in vitro, with higher concentrations leading to greater susceptibility. The method of testing is important in determining the anti-Helicobacter activity of proton pump inhibitors.
Full Text
The Full Text of this article is available as a PDF (195.2 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Cardaci G., Lambert J. R., King R. G., Onishi N., Midolo P. Reduced amoxicillin uptake into human gastric mucosa when gastric juice pH is high. Antimicrob Agents Chemother. 1995 Sep;39(9):2084–2087. doi: 10.1128/aac.39.9.2084. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fellenius E., Berglindh T., Sachs G., Olbe L., Elander B., Sjöstrand S. E., Wallmark B. Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+)ATPase. Nature. 1981 Mar 12;290(5802):159–161. doi: 10.1038/290159a0. [DOI] [PubMed] [Google Scholar]
- Ghelani A. M., Hale S., Coleman H., Radziwonik H., Robertson C., Atkinson M. Lack of in vitro activity of omeprazole against Campylobacter pylori. J Clin Pathol. 1990 Feb;43(2):171–172. doi: 10.1136/jcp.43.2.171-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gustavson L. E., Kaiser J. F., Edmonds A. L., Locke C. S., DeBartolo M. L., Schneck D. W. Effect of omeprazole on concentrations of clarithromycin in plasma and gastric tissue at steady state. Antimicrob Agents Chemother. 1995 Sep;39(9):2078–2083. doi: 10.1128/aac.39.9.2078. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Iwahi T., Satoh H., Nakao M., Iwasaki T., Yamazaki T., Kubo K., Tamura T., Imada A. Lansoprazole, a novel benzimidazole proton pump inhibitor, and its related compounds have selective activity against Helicobacter pylori. Antimicrob Agents Chemother. 1991 Mar;35(3):490–496. doi: 10.1128/aac.35.3.490. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lindberg P., Nordberg P., Alminger T., Brändström A., Wallmark B. The mechanism of action of the gastric acid secretion inhibitor omeprazole. J Med Chem. 1986 Aug;29(8):1327–1329. doi: 10.1021/jm00158a001. [DOI] [PubMed] [Google Scholar]
- Mauch F., Bode G., Malfertheiner P. Identification and characterization of an ATPase system of Helicobacter pylori and the effect of proton pump inhibitors. Am J Gastroenterol. 1993 Oct;88(10):1801–1802. [PubMed] [Google Scholar]
- McGowan C. C., Cover T. L., Blaser M. J. The proton pump inhibitor omeprazole inhibits acid survival of Helicobacter pylori by a urease-independent mechanism. Gastroenterology. 1994 Sep;107(3):738–743. doi: 10.1016/0016-5085(94)90121-x. [DOI] [PubMed] [Google Scholar]
- Nagata K., Takagi E., Tsuda M., Nakazawa T., Satoh H., Nakao M., Okamura H., Tamura T. Inhibitory action of lansoprazole and its analogs against Helicobacter pylori: inhibition of growth is not related to inhibition of urease. Antimicrob Agents Chemother. 1995 Feb;39(2):567–570. doi: 10.1128/aac.39.2.567. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Retsema J. A., Brennan L. A., Girard A. E. Effects of environmental factors on the in vitro potency of azithromycin. Eur J Clin Microbiol Infect Dis. 1991 Oct;10(10):834–842. doi: 10.1007/BF01975836. [DOI] [PubMed] [Google Scholar]
- Suerbaum S., Leying H., Klemm K., Opferkuch W. Antibacterial activity of pantoprazole and omeprazole against Helicobacter pylori. Eur J Clin Microbiol Infect Dis. 1991 Feb;10(2):92–93. doi: 10.1007/BF01964416. [DOI] [PubMed] [Google Scholar]