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. 1974 Mar 23;1(5907):535–536. doi: 10.1136/bmj.1.5907.535

Interaction between Doxycycline and Barbiturates

P J Neuvonen, O Penttilä
PMCID: PMC1633645  PMID: 4817187

Abstract

In a cross-over study of five hospitalized patients the half life of doxycycline was significantly shortened after 10 days' treatment with phenobarbitone. In five patients on continuous barbiturate therapy the half life of doxycycline was even shorter. Barbiturates or other agents inducing drug metabolism should be used cautiously in combination with doxycycline, since this might result in therapeutically inadequate serum concentrations of the antibiotic.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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