Abstract
During an ultrastructural study of small-intestinal mucosa from a patient suffering from alpha-chain disease organisms were identified within the epithelial cytoplasm which showed the fine structural features of the coccidian group. Though coccidiosis is well recognized as causing a diarrhoeal and often lethal illness in animals it has been neglected as a cause of disease in man. Thus this finding may be significant and warrants further investigation into its possible role in the pathogenesis of alpha-chain disease.
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- Brandborg L. L., Goldberg S. B., Breidenbach W. C. Human coccidiosis--a possible cause of malabsorption. N Engl J Med. 1970 Dec 10;283(24):1306–1313. doi: 10.1056/NEJM197012102832403. [DOI] [PubMed] [Google Scholar]
- Doe W. F., Henry K., Hobbs J. R., Jones F. A., Dent C. E., Booth C. C. Five cases of alpha chain disease. Gut. 1972 Dec;13(12):947–957. doi: 10.1136/gut.13.12.947. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Draper C. C., Killick-Kindrick R., Hutchison W. M., Garnham P. C. Experimental toxoplasmosis in chimpanzees. Br Med J. 1971 May 15;2(5758):375–378. doi: 10.1136/bmj.2.5758.375. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Huldt G., Gard S., Olovson S. G. Effect of Toxoplasma gondii on the thymus. Nature. 1973 Aug 3;244(5414):301–303. doi: 10.1038/244301a0. [DOI] [PubMed] [Google Scholar]
- Hutchison W. M., Dunachie J. F., Siim J. C., Work K. Coccidian-like nature of Toxoplasma gondii. Br Med J. 1970 Jan 17;1(5689):142–144. doi: 10.1136/bmj.1.5689.142. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Novis B. H., Bank S., Marks I. N., Selzer G., Kahn L., Sealy R. Abdominal lymphoma presenting with malabsorption. Q J Med. 1971 Oct;40(160):521–540. [PubMed] [Google Scholar]
- Rambaud J. C., Bognel C., Prost A., Bernier J. J., Le Quintrec Y., Lambling A., Danon F., Hurez D., Seligmann M. Clinico-pathological study of a patient with "Mediterranean" type of abdominal lymphoma and a new type of IgA abnormality ("alpha chain disease"). Digestion. 1968;1(6):321–336. doi: 10.1159/000196874. [DOI] [PubMed] [Google Scholar]
- Rogé J., Druet P., Marche C. Lymphome méditerranéen avec maladie des chaînes alpha. Triple rémission clinique, anatomique et immunologique. Pathol Biol (Paris) 1970 Oct;18(19):851–858. [PubMed] [Google Scholar]
- Seligmann M., Danon F., Hurez D., Mihaesco E., Preud'homme J. L. Alpha-chain disease: a new immunoglobulin abnormality. Science. 1968 Dec 20;162(3860):1396–1397. doi: 10.1126/science.162.3860.1396. [DOI] [PubMed] [Google Scholar]
- Seligmann M., Mihaesco E., Frangione B. Alpha chain disease. Ann N Y Acad Sci. 1971 Dec 31;190:487–500. doi: 10.1111/j.1749-6632.1971.tb13558.x. [DOI] [PubMed] [Google Scholar]
- Smitskamp H., Oey-Muller E. Geographical distribution and clinical significance of human coccidiosis. Trop Geogr Med. 1966 Jun;18(2):133–136. [PubMed] [Google Scholar]
- Stoop J. W., Ballieux R. E., Hijmans W., Zegers B. J. Alpha-chain disease with involvement of the respiratory tract in a Dutch child. Clin Exp Immunol. 1971 Nov;9(5):625–635. [PMC free article] [PubMed] [Google Scholar]
- Strickland G. T., Voller A., Pettit L. E., Fleck D. G. Immunodepression associated with concomitant toxoplasma and malarial infections in mice. J Infect Dis. 1972 Jul;126(1):54–60. doi: 10.1093/infdis/126.1.54. [DOI] [PubMed] [Google Scholar]
- Zlotnick A., Levy M. Alpha heavy chain disease. A variant of Mediterranean lymphoma. Arch Intern Med. 1971 Sep;128(3):432–436. doi: 10.1001/archinte.128.3.432. [DOI] [PubMed] [Google Scholar]




