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. 1996 Jul;40(7):1690–1694. doi: 10.1128/aac.40.7.1690

Characterization of tetracycline and erythromycin resistance determinants in Treponema denticola.

M C Roberts 1, W O Chung 1, D E Roe 1
PMCID: PMC163396  PMID: 8807063

Abstract

Treponema denticola isolates were evaluated for the presence of known tetracycline and erythromycin resistance determinants by Southern blot hybridization of whole-cell DNA and PCR assays. We examined all isolates available, which included 12 clinical and 4 American Type Culture Collection isolates. Two isolates carried the Tet B determinant, five isolates carried both the Tet B and Erm F determinants, seven isolates carried the Erm F determinant, and two did not carry any of the Tet or Erm determinants tested. Both the Tet B and Erm F determinants appeared to be associated with the chromosome. Neither of the two T. denticola donors tested could transfer the Tet B determinant, but three of four T. denticola tested transferred the Erm F determinant to an Enterococcus faecalis recipient. This extends the host range of both the tetB and ermF genes into the genus Treponema.

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Selected References

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