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. 1996 Jul;40(7):1717–1719. doi: 10.1128/aac.40.7.1717

Enhanced oxidative killing of azole-resistant Candida glabrata strains with ERG11 deletion.

V L Kan 1, A Geber 1, J E Bennett 1
PMCID: PMC163402  PMID: 8807069

Abstract

The susceptibility of genetically defined Candida glabrata strains to killing by H2O2 and neutrophils was assessed. Fluconazole-susceptible L5L and L5D strains demonstrated survival rates higher than those of two fluconazole-resistant strains lacking the ERG11 gene coding for 14 alpha-demethylase. Fluconazole resistance can occur by mechanisms which increase fungal susceptibility to oxidative killing by H2O2 and neutrophils.

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Selected References

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