Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1996 Aug;40(8):1924–1925. doi: 10.1128/aac.40.8.1924

Antimicrobial susceptibilities of Campylobacter jejuni and Campylobacter coli to 12 beta-lactam agents and combinations with beta-lactamase inhibitors.

P Tajada 1, J L Gomez-Graces 1, J I Alós 1, D Balas 1, R Cogollos 1
PMCID: PMC163441  PMID: 8843305

Abstract

The in vitro activities of 12 beta-lactam agents against 100 thermophilic Campylobacter strains were tested. Beta-Lactamase production was detected in 88% of all strains tested. Clavulanic acid was the best inhibitor by susceptibility testing. The beta-lactams which displayed high levels of in vitro activity against Campylobacter isolates were imipenem, amoxicillin-clavulanic acid, and cefepime and, to a lesser degree, amoxicillin, ampicillin, and cefotaxime.

Full Text

The Full Text of this article is available as a PDF (165.3 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allos B. M., Blaser M. J. Campylobacter jejuni and the expanding spectrum of related infections. Clin Infect Dis. 1995 May;20(5):1092–1101. doi: 10.1093/clinids/20.5.1092. [DOI] [PubMed] [Google Scholar]
  2. Fliegelman R. M., Petrak R. M., Goodman L. J., Segreti J., Trenholme G. M., Kaplan R. L. Comparative in vitro activities of twelve antimicrobial agents against Campylobacter species. Antimicrob Agents Chemother. 1985 Mar;27(3):429–430. doi: 10.1128/aac.27.3.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gaudreau C. L., Lariviere L. A., Lauzer J. C., Turgeon F. F. Effect of clavulanic acid on susceptibility of Campylobacter jejuni and Campylobacter coli to eight beta-lactam antibiotics. Antimicrob Agents Chemother. 1987 Jun;31(6):940–942. doi: 10.1128/aac.31.6.940. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Gomez-Garces J. L., Cogollos R., Alos J. L. Susceptibilities of fluoroquinolone-resistant strains of Campylobacter jejuni to 11 oral antimicrobial agents. Antimicrob Agents Chemother. 1995 Feb;39(2):542–544. doi: 10.1128/aac.39.2.542. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Lachance N., Gaudreau C., Lamothe F., Larivière L. A. Role of the beta-lactamase of Campylobacter jejuni in resistance to beta-lactam agents. Antimicrob Agents Chemother. 1991 May;35(5):813–818. doi: 10.1128/aac.35.5.813. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Lachance N., Gaudreau C., Lamothe F., Turgeon F. Susceptibilities of beta-lactamase-positive and -negative strains of Campylobacter coli to beta-lactam agents. Antimicrob Agents Chemother. 1993 May;37(5):1174–1176. doi: 10.1128/aac.37.5.1174. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lariviere L. A., Gaudreau C. L., Turgeon F. F. Susceptibility of clinical isolates of Campylobacter jejuni to twenty-five antimicrobial agents. J Antimicrob Chemother. 1986 Dec;18(6):681–685. doi: 10.1093/jac/18.6.681. [DOI] [PubMed] [Google Scholar]
  8. Page W. J., Huyer G., Huyer M., Worobec E. A. Characterization of the porins of Campylobacter jejuni and Campylobacter coli and implications for antibiotic susceptibility. Antimicrob Agents Chemother. 1989 Mar;33(3):297–303. doi: 10.1128/aac.33.3.297. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Penner J. L. The genus Campylobacter: a decade of progress. Clin Microbiol Rev. 1988 Apr;1(2):157–172. doi: 10.1128/cmr.1.2.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Reina J., Ros M. J., Serra A. Susceptibilities to 10 antimicrobial agents of 1,220 Campylobacter strains isolated from 1987 to 1993 from feces of pediatric patients. Antimicrob Agents Chemother. 1994 Dec;38(12):2917–2920. doi: 10.1128/aac.38.12.2917. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Taylor D. E., Courvalin P. Mechanisms of antibiotic resistance in Campylobacter species. Antimicrob Agents Chemother. 1988 Aug;32(8):1107–1112. doi: 10.1128/aac.32.8.1107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Van der Auwera P., Scorneaux B. In vitro susceptibility of Campylobacter jejuni to 27 antimicrobial agents and various combinations of beta-lactams with clavulanic acid or sulbactam. Antimicrob Agents Chemother. 1985 Jul;28(1):37–40. doi: 10.1128/aac.28.1.37. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES