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. 1996 Sep;40(9):2187–2189. doi: 10.1128/aac.40.9.2187

katG mutations in isoniazid-resistant Mycobacterium tuberculosis isolates recovered from Finnish patients.

H J Marttila 1, H Soini 1, P Huovinen 1, M K Viljanen 1
PMCID: PMC163496  PMID: 8878604

Abstract

katG and inhA genes from isoniazid-resistant Mycobacterium tuberculosis strains isolated in Finland were examined by PCR or sequencing. By PCR, katG was not detected in 3 of 54 strains. Sequencing of katG from 13 strains showed small point mutations or insertions; a previously described mutation causing a Ser-to-Thr change at position 315 was found in 4 strains, and there were nine new missense mutations of katG. A 209-bp segment of inhA from 17 strains was sequenced, but no mutations were observed. This result indicates that different mutations prevail in different geographical areas.

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Selected References

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