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. 1996 Oct;40(10):2413–2415. doi: 10.1128/aac.40.10.2413

Comparison of Etest to broth microdilution method for testing Streptococcus pneumoniae susceptibility to levofloxacin and three macrolides.

S Hunt Gerardo 1, D M Citron 1, M C Claros 1, E J Goldstein 1
PMCID: PMC163544  PMID: 8891154

Abstract

When the Etest was compared to broth microdilution for susceptibility testing of Streptococcus pneumoniae, levofloxacin, erythromycin, and penicillin results correlated for both methods; azithromycin and clarithromycin showed discrepancies of > or = 2 dilutions for 95.8% and 31.5% of the isolates, respectively. Levofloxacin was active against 141 of 142 isolates (< or = 2.0 micrograms/ml), making it a potentially useful new fluoroquinolone.

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Selected References

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  1. Appelbaum P. C. Antimicrobial resistance in Streptococcus pneumoniae: an overview. Clin Infect Dis. 1992 Jul;15(1):77–83. doi: 10.1093/clinids/15.1.77. [DOI] [PubMed] [Google Scholar]
  2. Barry A. L., Fuchs P. C. In-vitro potency of azithromycin against gram-negative bacilli is method-dependent. J Antimicrob Chemother. 1991 Oct;28(4):607–610. doi: 10.1093/jac/28.4.607. [DOI] [PubMed] [Google Scholar]
  3. Doern G. V., Brueggemann A., Holley H. P., Jr, Rauch A. M. Antimicrobial resistance of Streptococcus pneumoniae recovered from outpatients in the United States during the winter months of 1994 to 1995: results of a 30-center national surveillance study. Antimicrob Agents Chemother. 1996 May;40(5):1208–1213. doi: 10.1128/aac.40.5.1208. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Goldstein E. J., Sutter V. L. Effect of carbon dioxide on erythromycin. Antimicrob Agents Chemother. 1983 Feb;23(2):325–327. doi: 10.1128/aac.23.2.325. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Jacobs M. R., Bajaksouzian S., Appelbaum P. C., Bolmström A. Evaluation of the E-Test for susceptibility testing of pneumococci. Diagn Microbiol Infect Dis. 1992 Jul;15(5):473–478. doi: 10.1016/0732-8893(92)90093-9. [DOI] [PubMed] [Google Scholar]
  6. Jorgensen J. H., Ferraro M. J., McElmeel M. L., Spargo J., Swenson J. M., Tenover F. C. Detection of penicillin and extended-spectrum cephalosporin resistance among Streptococcus pneumoniae clinical isolates by use of the E test. J Clin Microbiol. 1994 Jan;32(1):159–163. doi: 10.1128/jcm.32.1.159-163.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kiska D. L., Kerr A., Jones M. C., Chazotte N. N., Eskridge B., Miller S., Jordan M., Sheaffer C., Gilligan P. H. Comparison of antimicrobial susceptibility methods for detection of penicillin-resistant Streptococcus pneumoniae. J Clin Microbiol. 1995 Jan;33(1):229–232. doi: 10.1128/jcm.33.1.229-232.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Klugman K. P. Pneumococcal resistance to antibiotics. Clin Microbiol Rev. 1990 Apr;3(2):171–196. doi: 10.1128/cmr.3.2.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Neu H. C., Chin N. X. In vitro activity of S-ofloxacin. Antimicrob Agents Chemother. 1989 Jul;33(7):1105–1107. doi: 10.1128/aac.33.7.1105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Retsema J. A., Brennan L. A., Girard A. E. Effects of environmental factors on the in vitro potency of azithromycin. Eur J Clin Microbiol Infect Dis. 1991 Oct;10(10):834–842. doi: 10.1007/BF01975836. [DOI] [PubMed] [Google Scholar]
  11. Spangler S. K., Jacobs M. R., Appelbaum P. C. Comparative activity of the new fluoroquinolone Bay y3118 against 177 penicillin susceptible and resistant pneumococci. Eur J Clin Microbiol Infect Dis. 1993 Dec;12(12):965–967. doi: 10.1007/BF01992176. [DOI] [PubMed] [Google Scholar]
  12. Spangler S. K., Jacobs M. R., Appelbaum P. C. Susceptibilities of penicillin-susceptible and -resistant strains of Streptococcus pneumoniae to RP 59500, vancomycin, erythromycin, PD 131628, sparfloxacin, temafloxacin, win 57273, ofloxacin, and ciprofloxacin. Antimicrob Agents Chemother. 1992 Apr;36(4):856–859. doi: 10.1128/aac.36.4.856. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Spika J. S., Facklam R. R., Plikaytis B. D., Oxtoby M. J. Antimicrobial resistance of Streptococcus pneumoniae in the United States, 1979-1987. The Pneumococcal Surveillance Working Group. J Infect Dis. 1991 Jun;163(6):1273–1278. doi: 10.1093/infdis/163.6.1273. [DOI] [PubMed] [Google Scholar]
  14. Une T., Fujimoto T., Sato K., Osada Y. In vitro activity of DR-3355, an optically active ofloxacin. Antimicrob Agents Chemother. 1988 Sep;32(9):1336–1340. doi: 10.1128/aac.32.9.1336. [DOI] [PMC free article] [PubMed] [Google Scholar]

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