biophysics. For the article “A molecular mechanism for osmolyte-induced protein stability,” by Timothy O. Street, D. Wayne Bolen, and George D. Rose, which appeared in issue 38, September 19, 2006, of Proc Natl Acad Sci USA (103:13997–14002; first published September 12, 2006; 10.1073/pnas.0606236103), the authors note the following: “For Fig. 2 of our article, we inadvertently published a plot of the contact surface area rather than the accessible surface area as intended. Also, the correlation coefficient given should be 0.81, not 0.88 as in the original figure caption. All other aspects of the article remain unaffected by this correction. We regret the errors.” The corrected figure and legend appear below.
Fig. 2.
The polar fraction of osmolyte surface correlates with measured Δgtr values. Fractional polar SA, fpolar surfaceosmolyte, is plotted against Δgtr values from Table 1 for the 10 osmolytes in Fig. 1. The linear regression line (solid line) has a negative slope with a correlation coefficient of 0.81, indicating that backbone/osmolyte interactions become increasingly favorable as osmolytes become increasingly polar.