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. 1997 Jan;41(1):191–192. doi: 10.1128/aac.41.1.191

Efficacy of lasalocid against murine Pneumocystis carinii pneumonitis.

H S OZ 1, W T Hughes 1, J E Rehg 1
PMCID: PMC163684  PMID: 8980779

Abstract

The efficacy of the ionophore lasalocid against Pneumocystis carinii pneumonitis in corticosteroid-immunosuppressed Sprague-Dawley rats was investigated. Lasalocid was effective in the prevention of the pneumonitis in a dose-dependent manner. At dosages of 0, 5, 10, and 20 mg/kg/day, P. carinii infection rates were 92, 60, 20, and 0%, respectively, during dexamethasone immunosuppression. Also, lasalocid compared favorably with other drugs known to have anti-P. carinii activity, including trimethoprim-sulfamethoxazole, atovaquone, and dapsone-trimethoprim.

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Selected References

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