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. 1997 Jan;41(1):215–217. doi: 10.1128/aac.41.1.215

In vitro susceptibility of Helicobacter pylori to protolichesterinic acid from the lichen Cetraria islandica.

K Ingolfsdottir 1, M A Hjalmarsdottir 1, A Sigurdsson 1, G A Gudjonsdottir 1, A Brynjolfsdottir 1, O Steingrimsson 1
PMCID: PMC163690  PMID: 8980785

Abstract

With reference to the traditional use of Cetraria islandica (Iceland moss) for relief of gastric and duodenal ulcer, plant extracts were screened for in vitro activity against Helicobacter pylori. (+)-Protolichesterinic acid, an aliphatic alpha-methylene-gamma-lactone, was identified as an active component. The MIC range of protolichesterinic acid, in free as well as salt form, was 16 to 64 micrograms/ml.

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Selected References

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  1. Fukuoka F., Nakanishi M., Shibata S., Nishikawa Y., Takeda T., Tanaka M. Polysaccharides in lichens and fungi. II. Anti-tumor activities on sarcoma-180 of the polysaccharide preparations from Gyrophora esculenta Miyoshi, Cetraria islandica (L.) Ach. var. orientalis Asahina, and some other lichens. Gan. 1968 Oct;59(5):421–432. [PubMed] [Google Scholar]
  2. Hirayama T., Fujikawa F., Kasahara T., Otsuka M., Nishida N., Mizuno D. [Anti-tumor activities of some lichen products and their degradation products (author's transl)]. Yakugaku Zasshi. 1980 Jul;100(7):755–759. doi: 10.1248/yakushi1947.100.7_755. [DOI] [PubMed] [Google Scholar]
  3. Houben G. M., Stockbrügger R. W. Bacteria in the aetio-pathogenesis of gastric cancer: a review. Scand J Gastroenterol Suppl. 1995;212:13–18. doi: 10.3109/00365529509090296. [DOI] [PubMed] [Google Scholar]
  4. Ingolfsdottir K., Jurcic K., Fischer B., Wagner H. Immunologically active polysaccharide from Cetraria islandica. Planta Med. 1994 Dec;60(6):527–531. doi: 10.1055/s-2006-959564. [DOI] [PubMed] [Google Scholar]
  5. Ingólfsdóttir K., Bloomfield S. F., Hylands P. J. In vitro evaluation of the antimicrobial activity of lichen metabolites as potential preservatives. Antimicrob Agents Chemother. 1985 Aug;28(2):289–292. doi: 10.1128/aac.28.2.289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Marshall B. J., Armstrong J. A., McGechie D. B., Glancy R. J. Attempt to fulfil Koch's postulates for pyloric Campylobacter. Med J Aust. 1985 Apr 15;142(8):436–439. doi: 10.5694/j.1326-5377.1985.tb113443.x. [DOI] [PubMed] [Google Scholar]
  7. Pengsuparp T., Cai L., Constant H., Fong H. H., Lin L. Z., Kinghorn A. D., Pezzuto J. M., Cordell G. A., Ingolfsdóttir K., Wagner H. Mechanistic evaluation of new plant-derived compounds that inhibit HIV-1 reverse transcriptase. J Nat Prod. 1995 Jul;58(7):1024–1031. doi: 10.1021/np50121a006. [DOI] [PubMed] [Google Scholar]
  8. STOLL A., BRACK A., RENZ J. Die Wirkung von Flechtenstoffen auf Tuberkelbakterien und auf einige andere Mikroorganismen; 7. Mitteilung über antibakterielle Stoffe. Schweiz Z Pathol Bakteriol. 1950;13(6):729–751. [PubMed] [Google Scholar]
  9. Salmon J. A., Garland L. G. Leukotriene antagonists and inhibitors of leukotriene biosynthesis as potential therapeutic agents. Prog Drug Res. 1991;37:9–90. doi: 10.1007/978-3-0348-7139-6_1. [DOI] [PubMed] [Google Scholar]

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