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. 1977 Oct;20:75–96. doi: 10.1289/ehp.772075

Environmental effects on the central nervous system.

G W Paulson
PMCID: PMC1637320  PMID: 202447

Abstract

The central nervous system (CNS) is designed to respond to the environment and is peculiarly vulnerable to many of the influences found in the environment. Utilizing an anatomical classification (cortex, cerebellum, peripheral nerves) major toxins and stresses are reviewed with selections from recent references. Selective vulnerability of certain areas to particular toxins is apparent at all levels of the CNS, although the amount of damage produced by any noxious agent depends on the age and genetic substrate of the subject. It is apparent that the effects of certain well known and long respected environmental toxins such as lead, mercury, etc., deserve continued surveillance. In addition, the overwhelming impact on the CNS of social damages such as trauma, alcohol, and tobacco cannot be ignored by environmentalists. The effect of the hospital and therapeutic environment has become apparent in view of increased awareness of iatrogenic disorders. The need for particular laboratory tests, for example, examination of CSF and nerve conduction toxicity studies, is suggested. Epidemics such as the recent solvent neuropathies suggest a need for continued animal studies that are chronic, as well as acute evaluations when predicting the potential toxic effects of industrial compounds.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahmann P. A., Smith S. A., Schwartz J. F., Clark D. B. Spinal cord infarction due to minor trauma in children. Neurology. 1975 Apr;25(4):301–307. doi: 10.1212/wnl.25.4.301. [DOI] [PubMed] [Google Scholar]
  2. Allen R. H., Eiseman B., Straehley C. J., Orloff B. G. Surfing injuries At waikiki. JAMA. 1977 Feb 14;237(7):668–670. [PubMed] [Google Scholar]
  3. BIDSTRUP P. L., BONNELL J. A., BECKETT A. G. Paralysis following poisoning by a new organic phosphorus insecticide (mipafox); report on two cases. Br Med J. 1953 May 16;1(4819):1068–1072. doi: 10.1136/bmj.1.4819.1068. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bank W. J., Pleasure D. E., Suzuki K., Nigro M., Katz R. Thallium poisoning. Arch Neurol. 1972 May;26(5):456–464. doi: 10.1001/archneur.1972.00490110090009. [DOI] [PubMed] [Google Scholar]
  5. Banta R. G., Markesbery W. R. Elevated manganese levels associated with dementia and extrapyramidal signs. Neurology. 1977 Mar;27(3):213–216. doi: 10.1212/wnl.27.3.213. [DOI] [PubMed] [Google Scholar]
  6. Beevers D. G., Erskine E., Robertson M., Beattie A. D., Campbell B. C., Goldberg A., Moore M. R., Hawthorne V. M. Blood-lead and hypertension. Lancet. 1976 Jul 3;2(7975):1–3. [PubMed] [Google Scholar]
  7. Billmaier D., Allen N., Craft B., Williams N., Epstein S., Fontaine R. Peripheral neuropathy in a coated fabrics plant. J Occup Med. 1974 Oct;16(10):665–671. [PubMed] [Google Scholar]
  8. Buchanan T. M., Faber L. C., Feldman R. A. Brucellosis in the United States, 1960-1972. An abattoir-associated disease. Part I. Clinical features and therapy. Medicine (Baltimore) 1974 Nov;53(6):403–413. doi: 10.1097/00005792-197411000-00001. [DOI] [PubMed] [Google Scholar]
  9. Buxton P. H., Hayward M. Polyneuritis cranialis associated with industrial trichloroethylene poisoning. J Neurol Neurosurg Psychiatry. 1967 Dec;30(6):511–518. doi: 10.1136/jnnp.30.6.511. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Carlisle E. M. Proceedings: Silicon as an essential element. Fed Proc. 1974 Jun;33(6):1758–1766. [PubMed] [Google Scholar]
  11. Catalano P. M. Hexachlorophene-not a cry of "wolf". Arch Dermatol. 1975 Feb;111(2):250–251. [PubMed] [Google Scholar]
  12. Caveness W. F. Epilepsy, a product of trauma in our time. Epilepsia. 1976 Jun;17(2):207–215. doi: 10.1111/j.1528-1157.1976.tb03398.x. [DOI] [PubMed] [Google Scholar]
  13. Chambers T. L. Hypernatraemia: a preventable cause of acquired brain damage? Dev Med Child Neurol. 1975 Feb;17(1):91–94. doi: 10.1111/j.1469-8749.1975.tb04963.x. [DOI] [PubMed] [Google Scholar]
  14. Chang H. C., Hermann E. R. Acoustical study of a rapid transit system. Am Ind Hyg Assoc J. 1974 Oct;35(10):640–653. doi: 10.1080/0002889748507084. [DOI] [PubMed] [Google Scholar]
  15. Chang L. W., Yamaguchi S., Dudley A. W., Jr Neurological changes in cats following long-term diet of mercury contaminated tuna. Acta Neuropathol. 1974 Feb 28;27(2):171–176. doi: 10.1007/BF00687167. [DOI] [PubMed] [Google Scholar]
  16. Cherington M. Botulism. Ten-year experience. Arch Neurol. 1974 Jun;30(6):432–437. doi: 10.1001/archneur.1974.00490360008003. [DOI] [PubMed] [Google Scholar]
  17. Chmouliovsky M., Dunant Y., Graf J., Straub R. W., Rufener C. Inhibition of creatine phosphokinase activity and synaptic transmission by black widow spider venom. Brain Res. 1972 Sep 15;44(1):289–293. doi: 10.1016/0006-8993(72)90386-1. [DOI] [PubMed] [Google Scholar]
  18. Chung H., Brown D. R. Mechanism of the effect of acute ethanol on hexobarbital metabolism. Biochem Pharmacol. 1976 Jul 15;25(14):1613–1616. doi: 10.1016/0006-2952(76)90472-x. [DOI] [PubMed] [Google Scholar]
  19. Clowes G. H., Jr, O'Donnell T. F., Jr Heat stroke. N Engl J Med. 1974 Sep 12;291(11):564–567. doi: 10.1056/NEJM197409122911106. [DOI] [PubMed] [Google Scholar]
  20. Cook D. G., Fahn S., Brait K. A. Chronic manganese intoxication. Arch Neurol. 1974 Jan;30(1):59–64. doi: 10.1001/archneur.1974.00490310061010. [DOI] [PubMed] [Google Scholar]
  21. Cooper W. C., Gaffey W. R. Mortality of lead workers. J Occup Med. 1975 Feb;17(2):100–107. doi: 10.1097/00043764-197502000-00012. [DOI] [PubMed] [Google Scholar]
  22. Coxon A., Pallis C. A. Metronidazole neuropathy. J Neurol Neurosurg Psychiatry. 1976 Apr;39(4):403–405. doi: 10.1136/jnnp.39.4.403. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Crane G. E. Clinical psychopharmacology in its 20th year. Late, unanticipated effects of neuroleptics may limit their use in psychiatry. Science. 1973 Jul 13;181(4095):124–128. doi: 10.1126/science.181.4095.124. [DOI] [PubMed] [Google Scholar]
  24. Crow T. J., Grove-White I. G. An analysis of the learning deficit following hyoscine administration to man. Br J Pharmacol. 1973 Oct;49(2):322–327. doi: 10.1111/j.1476-5381.1973.tb08379.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Cullen D. J., Ferrara L. C., Briggs B. A., Walker P. F., Gilbert J. Survival, hospitalization charges and follow-up results in critically ill patients. N Engl J Med. 1976 Apr 29;294(18):982–987. doi: 10.1056/NEJM197604292941805. [DOI] [PubMed] [Google Scholar]
  26. Currier R. W., 2nd, McCroan J. E., Dreesen D. W., Winkler W. G., Parker R. L. Epidemiology of antirabies treatment in Georgia, 1967-71. Public Health Rep. 1975 Sep-Oct;90(5):435–439. [PMC free article] [PubMed] [Google Scholar]
  27. Dales L. G. The neurotoxicity of alkyl mercury compounds. Am J Med. 1972 Aug;53(2):219–232. doi: 10.1016/0002-9343(72)90131-3. [DOI] [PubMed] [Google Scholar]
  28. David O., Clark J., Voeller K. Lead and hyperactivity. Lancet. 1972 Oct 28;2(7783):900–903. doi: 10.1016/s0140-6736(72)92534-2. [DOI] [PubMed] [Google Scholar]
  29. De la Burdé B., Reames B. Prevention of pica, the major cause of lead poisoning in children. Am J Public Health. 1973 Aug;63(8):737–743. doi: 10.2105/ajph.63.8.737. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Dowd P. J. Influence of alcoholic beverages on the vestibulo-ocular responses to Coriolis stimulation. Q J Stud Alcohol. 1974 Sep;35(3):943–952. [PubMed] [Google Scholar]
  31. Drysdale W. F., Kraus J. F., Franti C. E., Riggins R. S. Injury patterns in motorcycle collisions. J Trauma. 1975 Feb;15(2):99–115. doi: 10.1097/00005373-197502000-00003. [DOI] [PubMed] [Google Scholar]
  32. Dudley A. W., Jr, Thapar N. T. Fatal human ingestion of 2,4-D, a common herbicide. Arch Pathol. 1972 Sep;94(3):270–275. [PubMed] [Google Scholar]
  33. Duffy P., Wolf J., Collins G., DeVoe A. G., Streeten B., Cowen D. Letter: Possible person-to-person transmission of Creutzfeldt-Jakob disease. N Engl J Med. 1974 Mar 21;290(12):692–693. [PubMed] [Google Scholar]
  34. Dully F. E., Jr Central nervous system involvement following type I aviator's bends complicated by complacency. Aviat Space Environ Med. 1975 Sep;46(9):1186–1187. [PubMed] [Google Scholar]
  35. Earnest M. P., Yarnell P. R. Seizure admissions to a city hospital: the role of alcohol. Epilepsia. 1976 Dec;17(4):387–393. doi: 10.1111/j.1528-1157.1976.tb04450.x. [DOI] [PubMed] [Google Scholar]
  36. Einhorn V. F., Hamilton R. C. Red back spider venom and inhibitory transmission. J Pharm Pharmacol. 1974 Sep;26(9):748–750. doi: 10.1111/j.2042-7158.1974.tb09367.x. [DOI] [PubMed] [Google Scholar]
  37. Erenberg G., Rinsler S. S., Fish B. G. Lead neuropathy and sickle cell disease. Pediatrics. 1974 Oct;54(4):438–441. [PubMed] [Google Scholar]
  38. Evans H. L., Laties V. G., Weiss B. Behavioral effects of mercury and methylmercury. Fed Proc. 1975 Aug;34(9):1858–1867. [PubMed] [Google Scholar]
  39. Feldman R. G., Sedman T. Letter: Hobbyists working with lead. N Engl J Med. 1975 Apr 24;292(17):929–929. [PubMed] [Google Scholar]
  40. Fielding J. E., Walsh D. C. Comprehensive health care and motor-vehicle safety. N Engl J Med. 1976 Apr 8;294(15):841–843. doi: 10.1056/NEJM197604082941515. [DOI] [PubMed] [Google Scholar]
  41. Garland T. O., Patterson M. W. Six cases of acrylamide poisoning. Br Med J. 1967 Oct 28;4(5572):134–138. doi: 10.1136/bmj.4.5572.134. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Gilroy J., Andaya L., Thomas V. J. Intracranial mycotic aneurysms and subacute bacterial endocarditis in heroin addiction. Neurology. 1973 Nov;23(11):1193–1198. doi: 10.1212/wnl.23.11.1193. [DOI] [PubMed] [Google Scholar]
  43. Ginsberg M. D., Myers R. E. Fetal brain damage following maternal carbon monoxide intoxication: an experimental study. Acta Obstet Gynecol Scand. 1974;53(4):309–317. doi: 10.3109/00016347409157744. [DOI] [PubMed] [Google Scholar]
  44. Gordon A. S., Prichard J. S., Freedman M. H. Seizure disorders and anemia associated with chronic borax intoxication. Can Med Assoc J. 1973 Mar 17;108(6):719–passim. [PMC free article] [PubMed] [Google Scholar]
  45. Goto I., Matsumura M., Inoue N., Murai Y., Shida K. Toxic polyneuropathy due to glue sniffing. J Neurol Neurosurg Psychiatry. 1974 Jul;37(7):848–853. doi: 10.1136/jnnp.37.7.848. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Guinee V. F. Lead poisoning. Am J Med. 1972 Mar;52(3):283–288. doi: 10.1016/0002-9343(72)90015-0. [DOI] [PubMed] [Google Scholar]
  47. Gupta P. K., Kohli J. D. Acute toxicity of Iomex--a petroleum weedicide. Bull Environ Contam Toxicol. 1975 Aug;14(2):241–249. doi: 10.1007/BF01701321. [DOI] [PubMed] [Google Scholar]
  48. Gutierrez F. A., Raimondi A. J. Delayed onset of acute posttraumatic subdural effusion. Am J Dis Child. 1974 Sep;128(3):327–331. doi: 10.1001/archpedi.1974.02110280057007. [DOI] [PubMed] [Google Scholar]
  49. HUBEL D. H., WIESEL T. N. RECEPTIVE FIELDS OF CELLS IN STRIATE CORTEX OF VERY YOUNG, VISUALLY INEXPERIENCED KITTENS. J Neurophysiol. 1963 Nov;26:994–1002. doi: 10.1152/jn.1963.26.6.994. [DOI] [PubMed] [Google Scholar]
  50. Haas D. C., Marasigan A. Neurological effects of glutethimide. J Neurol Neurosurg Psychiatry. 1968 Dec;31(6):561–564. doi: 10.1136/jnnp.31.6.561. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Hankin L., Heichel G. H., Botsford R. A. Lead in pet foods and processed organ meats. A human problem? JAMA. 1975 Feb 3;231(5):484–485. [PubMed] [Google Scholar]
  52. Hanson J. W., Smith D. W., Cohen M. M., Jr Prominent lateral palatine ridges: developmental and clinical relevance. J Pediatr. 1976 Jul;89(1):54–58. doi: 10.1016/s0022-3476(76)80926-2. [DOI] [PubMed] [Google Scholar]
  53. Haynes S. G., Gibson J. B., Kurland L. T. Epidemiology of neural-tube defects and Down's syndrome in Rochester, Minnesota, 1935-1971. Neurology. 1974 Jul;24(7):691–700. doi: 10.1212/wnl.24.7.691. [DOI] [PubMed] [Google Scholar]
  54. Husby J., Sorensen K. H. Fracture of the odontoid process of the axis. Acta Orthop Scand. 1974;45(2):182–192. doi: 10.3109/17453677408989138. [DOI] [PubMed] [Google Scholar]
  55. Irstam L., Sundström R., Sigstedt B. Lumbar myelography and adhesive arachnoiditis. Acta Radiol Diagn (Stockh) 1974 Jul;15(4):356–368. doi: 10.1177/028418517401500402. [DOI] [PubMed] [Google Scholar]
  56. Jamieson K. G., Kelly D. Crash helmets reduce head injuries. Med J Aust. 1973 Oct 27;2(17):806–809. doi: 10.5694/j.1326-5377.1973.tb129780.x. [DOI] [PubMed] [Google Scholar]
  57. Johnson R. T., Johnson K. P. Hydrocephalus following viral infection: the pathology of aqueductal stenosis developing after experimental mumps virus infection. J Neuropathol Exp Neurol. 1968 Oct;27(4):591–606. [PubMed] [Google Scholar]
  58. Jones K. L., Smith D. W. The fetal alcohol syndrome. Teratology. 1975 Aug;12(1):1–10. doi: 10.1002/tera.1420120102. [DOI] [PubMed] [Google Scholar]
  59. KURLAND L. T., FARO S. N., SIEDLER H. Minamata disease. The outbreak of a neurologic disorder in Minamata, Japan, and its relationship to the ingestion of seafood contaminated by mercuric compounds. World Neurol. 1960 Nov;1:370–395. [PubMed] [Google Scholar]
  60. Kaplan M. L., Murphy S. D., Gilles F. H. Modification of acrylamide neuropathy in rats by selected factors. Toxicol Appl Pharmacol. 1973 Apr;24(4):564–570. doi: 10.1016/0041-008x(73)90218-4. [DOI] [PubMed] [Google Scholar]
  61. Kelly T. W. Prolonged cerebellar dysfunction associated with paint-sniffing. Pediatrics. 1975 Oct;56(4):605–606. [PubMed] [Google Scholar]
  62. Kewalramani L. S., Orth M. S., Taylor R. G. Injuries to the cervical spine from diving accidents. J Trauma. 1975 Feb;15(2):130–142. doi: 10.1097/00005373-197502000-00005. [DOI] [PubMed] [Google Scholar]
  63. Klein M. C., Sayre J. W., Kotok D. Lead poisoning. Current status of the problem facing pediatricians. Am J Dis Child. 1974 Jun;127(6):805–807. doi: 10.1001/archpedi.1974.02110250031004. [DOI] [PubMed] [Google Scholar]
  64. Knox J. W., Nelson J. R. Permanent encephalopathy from toluene inhalation. N Engl J Med. 1966 Dec 29;275(26):1494–1496. doi: 10.1056/NEJM196612292752608. [DOI] [PubMed] [Google Scholar]
  65. Kolata G. B. Brain biochemistry: effects of diet. Science. 1976 Apr 2;192(4234):41–42. doi: 10.1126/science.192.4234.41. [DOI] [PubMed] [Google Scholar]
  66. Korobkin R., Asbury A. K., Sumner A. J., Nielsen S. L. Glue-sniffing neuropathy. Arch Neurol. 1975 Mar;32(3):158–162. doi: 10.1001/archneur.1975.00490450038004. [DOI] [PubMed] [Google Scholar]
  67. Krager J. M., Safer D. J. Type and prevalence of medication used in the treatment of hyperactive children. N Engl J Med. 1974 Nov 21;291(21):1118–1120. doi: 10.1056/NEJM197411212912108. [DOI] [PubMed] [Google Scholar]
  68. Krishnamurti A., Kanagasuntheram R., Vij S. Effect of TOCP poisoning on the Pacinian corpuscles of slow loris. Acta Neuropathol. 1972;22(4):345–350. doi: 10.1007/BF00809245. [DOI] [PubMed] [Google Scholar]
  69. König H., Gassman H. B., Jenzer G. Ocular involvement in benign botulism B. Am J Ophthalmol. 1975 Sep;80(3 Pt 1):430–432. doi: 10.1016/0002-9394(75)90530-9. [DOI] [PubMed] [Google Scholar]
  70. Laitinen J., Puranen J., Vuorinen P. Vibration syndrome in lumbermen (working with chain saws). J Occup Med. 1974 Aug;16(8):552–556. [PubMed] [Google Scholar]
  71. Langdon D. E., Harlan J. R., Bailey R. L. Thrombophlebitis with diazepam used intravenously. JAMA. 1973 Jan 8;223(2):184–185. [PubMed] [Google Scholar]
  72. Lansdown R. G., Shepherd J., Clayton B. E., Delves H. T., Graham P. J., Turner W. C. Blood-lead levels, behaviour, and intelligence. A population study. Lancet. 1974 Mar 30;1(7857):538–541. doi: 10.1016/s0140-6736(74)92718-4. [DOI] [PubMed] [Google Scholar]
  73. Latham M. C. Protein-calorie malnutrition in children and its relation to psychological development and behavior. Physiol Rev. 1974 Jul;54(3):541–565. doi: 10.1152/physrev.1974.54.3.541. [DOI] [PubMed] [Google Scholar]
  74. Lemkey-Johnston N., Butler V., Reynolds W. A. Brain damage in neonatal mice following monosodium glutamate administration: possible involvement of hypernatremia and hyperosmolality. Exp Neurol. 1975 Aug;48(2):292–309. doi: 10.1016/0014-4886(75)90158-2. [DOI] [PubMed] [Google Scholar]
  75. Lin-Fu J. S. Undue absorption of lead among children--a new look at an old problem. N Engl J Med. 1972 Mar 30;286(13):702–710. doi: 10.1056/NEJM197203302861306. [DOI] [PubMed] [Google Scholar]
  76. Lock E. A. Increase in cerebral fluids in rats after treatment with hexachlorophane or triethyltin. Biochem Pharmacol. 1976 Jul 1;25(13):1455–1458. doi: 10.1016/0006-2952(76)90060-5. [DOI] [PubMed] [Google Scholar]
  77. Mallov J. S. MBK neuropathy among spray painters. JAMA. 1976 Apr 5;235(14):1455–1457. [PubMed] [Google Scholar]
  78. Matthews W. B. Footballer's migraine. Br Med J. 1972 May 6;2(5809):326–327. doi: 10.1136/bmj.2.5809.326. [DOI] [PMC free article] [PubMed] [Google Scholar]
  79. Mayer B. W., Schlackman N. Organophosphates--a pediatric hazard. Am Fam Physician. 1975 May;11(5):121–124. [PubMed] [Google Scholar]
  80. McALPINE D., ARAKI S. Minamata disease: an unusual neurological disorder caused by contaminated fish. Lancet. 1958 Sep 20;2(7047):629–631. doi: 10.1016/s0140-6736(58)90348-9. [DOI] [PubMed] [Google Scholar]
  81. McDonough J. R. Methyl n-butyl ketone. J Occup Med. 1974 Jun;16(6):412–412. [PubMed] [Google Scholar]
  82. Meade T. W. Subacute myelo-optic neuropathy and clioquinol. An epidemiological case-history for diagnosis. Br J Prev Soc Med. 1975 Sep;29(3):157–169. doi: 10.1136/jech.29.3.157. [DOI] [PMC free article] [PubMed] [Google Scholar]
  83. Means E. D., Prockop L. D., Hooper G. S. Pathology of lacquer thinner induced neuropathy. Ann Clin Lab Sci. 1976 May-Jun;6(3):240–250. [PubMed] [Google Scholar]
  84. Mendell J. R., Saida K., Ganansia M. F., Jackson D. B., Weiss H., Gardier R. W., Chrisman C., Allen N., Couri D., O'Neill J. Toxic polyneuropathy produced by methyl N-butyl ketone. Science. 1974 Aug 30;185(4153):787–789. doi: 10.1126/science.185.4153.787. [DOI] [PubMed] [Google Scholar]
  85. Merson M. H., Hughes J. M., Dowell V. R., Taylor A., Barker W. H., Gangarosa E. J. Current trends in botulism in the United States. JAMA. 1974 Sep 2;229(10):1305–1308. [PubMed] [Google Scholar]
  86. Mikolich J. R., Paulson G. W., Cross C. J. Acute anticholinergic syndrome due to Jimson seed ingestion. Clinical and laboratory observation in six cases. Ann Intern Med. 1975 Sep;83(3):321–325. doi: 10.7326/0003-4819-83-3-321. [DOI] [PubMed] [Google Scholar]
  87. Milunsky A., Alpert E. Sounding board: Antenatal diagnosis, alpha fetoprotein and the FDA. N Engl J Med. 1976 Jul 15;295(3):168–169. doi: 10.1056/NEJM197607152950312. [DOI] [PubMed] [Google Scholar]
  88. Nicol C. S., Oriel J. D. Letter: Minocycline: Possible vestibular side-effects. Lancet. 1974 Nov 23;2(7891):1260–1260. doi: 10.1016/s0140-6736(74)90767-3. [DOI] [PubMed] [Google Scholar]
  89. Olszewski W. A., Pillay K. K., Glomski C. A., Brody H. Mercury in the human brain. Acta Neurol Scand. 1974;50(5):581–588. doi: 10.1111/j.1600-0404.1974.tb02803.x. [DOI] [PubMed] [Google Scholar]
  90. Onoyama Y., Abe M., Takahashi M., Yabumoto E., Sakamoto T. Radiation therapy of brain tumors in children. Radiology. 1975 Jun;115(3):687–693. doi: 10.1148/15.3.687. [DOI] [PubMed] [Google Scholar]
  91. PARK A. M., RICHARDSON J. C. Cerebral complications of serum sickness. Neurology. 1953 Apr;3(4):277–283. doi: 10.1212/wnl.3.4.277. [DOI] [PubMed] [Google Scholar]
  92. Paulson G. W., Rawls R. Neurologic and psychologic assessment of institutionalized children with retrolental fibroplasia. Confin Neurol. 1968;30(4):209–216. doi: 10.1159/000103534. [DOI] [PubMed] [Google Scholar]
  93. Paulson G. W., Rizvi C. A., Crane G. E. Tardive dyskinesia as a possible sequel of long-term therapy with phenothiazines. Clin Pediatr (Phila) 1975 Oct;14(10):953–955. doi: 10.1177/000992287501401013. [DOI] [PubMed] [Google Scholar]
  94. Paulson G. W. Tardive dyskinesia. Annu Rev Med. 1975;26:75–81. doi: 10.1146/annurev.me.26.020175.000451. [DOI] [PubMed] [Google Scholar]
  95. Paulson G. W., Waylonis G. W. Polyneuropathy due to n-hexane. Arch Intern Med. 1976 Aug;136(8):880–882. [PubMed] [Google Scholar]
  96. Paulson G., Vergara G., Young J., Bird M. Thallium intoxication treated with dithizone and hemodialysis. Arch Intern Med. 1972 Jan;129(1):100–103. [PubMed] [Google Scholar]
  97. Porcine streptococci causing meningitis and septicaemia in man. Lancet. 1975 Jun 7;1(7919):1286–1288. [PubMed] [Google Scholar]
  98. Prineas J. The pathogenesis of dying-back polyneuropathies. II. An ultrastructural study of experimental acrylamide intoxication in the cat. J Neuropathol Exp Neurol. 1969 Oct;28(4):598–621. doi: 10.1097/00005072-196910000-00004. [DOI] [PubMed] [Google Scholar]
  99. Prosky L., O'Dell R. G. Effect of dietary monosodium L-glutamate on some brain and liver metabolites in rays. Proc Soc Exp Biol Med. 1971 Nov;138(2):517–522. doi: 10.3181/00379727-138-35930. [DOI] [PubMed] [Google Scholar]
  100. Ringel S. P., Klawans H. L., Jr Carbon monoxide-induced Parkinsonism. J Neurol Sci. 1972 Jul;16(3):245–251. doi: 10.1016/0022-510x(72)90190-6. [DOI] [PubMed] [Google Scholar]
  101. Robinson G. R., Wagstaff D. J., Colaianne J. J., Ulsamer A. G. Experimental hexachlorophene intoxication in young swine. Am J Vet Res. 1975 Nov;36(11):1615–1618. [PubMed] [Google Scholar]
  102. Rumack B. H. Anticholinergic poisoning: treatment with physostigmine. Pediatrics. 1973 Sep;52(3):449–451. [PubMed] [Google Scholar]
  103. SPILLANE J. D., WELLS C. E. THE NEUROLOGY OF JENNERIAN VACCINATION. A CLINICAL ACCOUNT OF THE NEUROLOGICAL COMPLICATIONS WHICH OCCURRED DURING THE SMALLPOX EPIDEMIC IN SOUTH WALES IN 1962. Brain. 1964 Mar;87:1–44. doi: 10.1093/brain/87.1.1. [DOI] [PubMed] [Google Scholar]
  104. Sachs H. K., Blanksma L. A., Murray E. F., O'Connell M. J. Ambulatory treatment of lead poisoning: report of 1,155 cases. Pediatrics. 1970 Sep;46(3):389–396. [PubMed] [Google Scholar]
  105. Sadowsky C. H., Sachs E., Jr, Ochoa J. Postradiation motor neuron syndrome. Arch Neurol. 1976 Nov;33(11):786–787. doi: 10.1001/archneur.1976.00500110054010. [DOI] [PubMed] [Google Scholar]
  106. Saida K., Mendell J. R., Weiss H. S. Peripheral nerve changes induced by methyl n-butyl ketone and potentiation by methyl ethyl ketone. J Neuropathol Exp Neurol. 1976 May;35(3):207–225. doi: 10.1097/00005072-197605000-00001. [DOI] [PubMed] [Google Scholar]
  107. Saslow A. R., Clark P. S. Carbon monoxide poisoning. Report of an outbreak involving 171 persons. J Occup Med. 1973 Jun;15(6):490–492. [PubMed] [Google Scholar]
  108. Sataloff J. Otology and industrial hearing conservation. Ann Otol Rhinol Laryngol. 1975 Jul-Aug;84(4 Pt 1):527–529. doi: 10.1177/000348947508400412. [DOI] [PubMed] [Google Scholar]
  109. Sayre J. W., Charney E., Vostal J., Pless I. B. House and hand dust as a potential source of childhood lead exposure. Am J Dis Child. 1974 Feb;127(2):167–170. doi: 10.1001/archpedi.1974.02110210017002. [DOI] [PubMed] [Google Scholar]
  110. Scharnweber H. C., Spears G. N., Cowles S. R. Case reports. Chronic methyl chloride intoxication in six industrial workers. J Occup Med. 1974 Feb;16(2):112–113. [PubMed] [Google Scholar]
  111. Schechter P. J., Henkin R. I. Abnormalities of taste and smell after head trauma. J Neurol Neurosurg Psychiatry. 1974 Jul;37(7):802–810. doi: 10.1136/jnnp.37.7.802. [DOI] [PMC free article] [PubMed] [Google Scholar]
  112. Schneider M. An environmental study of mercury contamination in dental offices. J Am Dent Assoc. 1974 Nov;89(5):1092–1098. doi: 10.14219/jada.archive.1974.0537. [DOI] [PubMed] [Google Scholar]
  113. Schwarz K. Proceedings: Recent dietary trace element research, exemplified by tin, fluorone, and silicon. Fed Proc. 1974 Jun;33(6):1748–1757. [PubMed] [Google Scholar]
  114. Shuman R. M., Leech R. W., Alvord E. C., Jr Neurotoxicity of topically applied hexachlorophene in the young rat. Arch Neurol. 1975 May;32(5):315–319. doi: 10.1001/archneur.1975.00490470059008. [DOI] [PubMed] [Google Scholar]
  115. Siddall J. R. The ocular toxic findings with prolonged and high dosage chlorpromazine intake. Arch Ophthalmol. 1965 Oct;74(4):460–464. doi: 10.1001/archopht.1965.00970040462005. [DOI] [PubMed] [Google Scholar]
  116. Smilack J. D. Group-y meningococcal disease. Twelve cases at an army training center. Ann Intern Med. 1974 Dec;81(6):740–745. doi: 10.7326/0003-4819-81-6-740. [DOI] [PubMed] [Google Scholar]
  117. Smith G. F. Trichlorethylene: a review. Br J Ind Med. 1966 Oct;23(4):249–262. [PMC free article] [PubMed] [Google Scholar]
  118. Smyth L. T., Ruhf R. C., Whitman N. E., Dugan T. Clinical manganism and exposure to manganese in the production and processing of ferromanganese alloy. J Occup Med. 1973 Feb;15(2):101–109. [PubMed] [Google Scholar]
  119. Snyder R. D. Carbon monoxide intoxication with peripheral neuropathy. Neurology. 1970 Feb;20(2):177–180. doi: 10.1212/wnl.20.2.177. [DOI] [PubMed] [Google Scholar]
  120. Snyder R. D. The involuntary movements of chronic mercury poisoning. Arch Neurol. 1972 Apr;26(4):379–381. doi: 10.1001/archneur.1972.00490100109013. [DOI] [PubMed] [Google Scholar]
  121. Somers A. R. Violence, television and the health of American youth. N Engl J Med. 1976 Apr 8;294(15):811–816. doi: 10.1056/NEJM197604082941505. [DOI] [PubMed] [Google Scholar]
  122. Specht E. E. Brachial plexus palsy in the newborn. Incidence and prognosis. Clin Orthop Relat Res. 1975 Jul-Aug;(110):32–34. doi: 10.1097/00003086-197507000-00006. [DOI] [PubMed] [Google Scholar]
  123. Suzuki K., Pfaff L. D. Acrylamide neuropathy in rats. An electron microscopic study of degeneration and regeneration. Acta Neuropathol. 1973 May 16;24(3):197–213. doi: 10.1007/BF00687590. [DOI] [PubMed] [Google Scholar]
  124. Swinne-Desgain D. Letter: The pigeon as reservoir for cryptococcus neoformans. Lancet. 1974 Oct 5;2(7884):842–843. doi: 10.1016/s0140-6736(74)91106-4. [DOI] [PubMed] [Google Scholar]
  125. Tabershaw I. R., Gaffey W. R. Mortality study of workers in the manufacture of vinyl chloride and its polymers. J Occup Med. 1974 Aug;16(8):509–518. [PubMed] [Google Scholar]
  126. Takemori S., Tanaka Y., Suzuki J. I. Thalidomide anomalies of the ear. Arch Otolaryngol. 1976 Jul;102(7):425–427. doi: 10.1001/archotol.1976.00780120073010. [DOI] [PubMed] [Google Scholar]
  127. Teo S. T., Newth J., Pascoe B. J. Chronic vitamin A intoxication. Med J Aust. 1973 Aug 18;2(7):324–326. doi: 10.5694/j.1326-5377.1973.tb128180.x. [DOI] [PubMed] [Google Scholar]
  128. Terrence C. F., Jr, Wisotzkey H. M., Perper J. A. Unexpected, unexplained death in epileptic patients. Neurology. 1975 Jun;25(6):594–598. doi: 10.1212/wnl.25.6.594. [DOI] [PubMed] [Google Scholar]
  129. Tibbles J. A., Brown B. S. Acute hemiplegia of childhood. Can Med Assoc J. 1975 Aug 23;113(4):309–314. [PMC free article] [PubMed] [Google Scholar]
  130. Towfighi J., Gonatas N. K., Pleasure D., Cooper H. S., McCree L. Glue sniffer's neuropathy. Neurology. 1976 Mar;26(3):238–243. doi: 10.1212/wnl.26.3.238. [DOI] [PubMed] [Google Scholar]
  131. Tsujihata M., Engel A. G., Lambert E. H. Motor end-plate fine structure in acrylamide dying-back neuropathy: a sequential morphometric study. Neurology. 1974 Sep;24(9):849–856. doi: 10.1212/wnl.24.9.849. [DOI] [PubMed] [Google Scholar]
  132. Valsamis M. P., Mancall E. Toxic cerebellar degeneration. Hum Pathol. 1973 Dec;4(4):513–520. doi: 10.1016/s0046-8177(73)80063-2. [DOI] [PubMed] [Google Scholar]
  133. Von Burg R., Rustam H. Electrophysiological investigations of methylmercury intoxication in humans. Evaluation of peripheral nerve by conduction velocity and electromyography. Electroencephalogr Clin Neurophysiol. 1974 Oct;37(4):381–392. doi: 10.1016/0013-4694(74)90113-8. [DOI] [PubMed] [Google Scholar]
  134. Vostal J. J., Clarkson T. W. Mercury as an environmental hazard. J Occup Med. 1973 Aug;15(8):649–656. [PubMed] [Google Scholar]
  135. Wada J. A., Osawa T. Spontaneous recurrent seizure state induced by daily electric amygdaloid stimulation in Senegalese baboons (Papio papio). Neurology. 1976 Mar;26(3):273–286. doi: 10.1212/wnl.26.3.273. [DOI] [PubMed] [Google Scholar]
  136. Wadia R. S., Sadagopan C., Amin R. B., Sardesai H. V. Neurological manifestations of organophosphorous insecticide poisoning. J Neurol Neurosurg Psychiatry. 1974 Jul;37(7):841–847. doi: 10.1136/jnnp.37.7.841. [DOI] [PMC free article] [PubMed] [Google Scholar]
  137. Walker-Smith J., Blomfield J. Wilson's disease or chronic copper poisoning? Arch Dis Child. 1973 Jun;48(6):476–479. doi: 10.1136/adc.48.6.476. [DOI] [PMC free article] [PubMed] [Google Scholar]
  138. Warlow C., Ogston D., Douglas A. S. Deep venous thrombosis of the legs after strokes. Part I--incidence and predisposing factors. Br Med J. 1976 May 15;1(6019):1178–1181. doi: 10.1136/bmj.1.6019.1178. [DOI] [PMC free article] [PubMed] [Google Scholar]
  139. Wender M., Radecka A. Histoenzymic studies of the central nervous system in tri-ortho-cresyl phosphate poisoning. Acta Histochem. 1973;47(2):204–215. [PubMed] [Google Scholar]
  140. Whitfield C. L., Ch'ien L. T., Whitehead J. D. Lead encephalopathy in adults. Am J Med. 1972 Mar;52(3):289–298. doi: 10.1016/0002-9343(72)90016-2. [DOI] [PubMed] [Google Scholar]

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