Skip to main content
NCBI home page
Environmental Health Perspectives logoLink to Environmental Health Perspectives
. 1979 Apr;29:81–87. doi: 10.1289/ehp.792981

Nutrient-toxicant interactions: susceptible populations.

K R Mahaffey, J E Vanderveen
PMCID: PMC1637364  PMID: 510246

Abstract

Nutritional status can substantially modify the toxicity of environmental pollutants. Investigations with experimental animals and epidemiological observations on humans have established the role of nutrition in altering susceptibility to a variety of pollutants including pesticides and heavy metals. The degree of nutritional deficiency that alters susceptibility need not be severe. Frequently only biochemical indications of nutritional deficiency can be associated with changes in the dose-response of an animal or person to a toxic compound.

Full text

PDF
81

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BORSOOK H., FISCHER E. H., KEIGHLEY G. Factors affecting protein synthesis in vitro in rabbit reticulocytes. J Biol Chem. 1957 Dec;229(2):1059–1070. [PubMed] [Google Scholar]
  2. Bailey-Wood R., Blayney L. M., Muir J. R., Jacobs A. The effects of iron deficiency on rat liver enzymes. Br J Exp Pathol. 1975 Jun;56(3):193–198. [PMC free article] [PubMed] [Google Scholar]
  3. Barltrop D., Khoo H. E. The influence of nutritional factors on lead absorption. Postgrad Med J. 1975 Nov;51(601):795–800. doi: 10.1136/pgmj.51.601.795. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Border E. A., Cantrell A. C., Kilroe-Smith T. A. The in vitro effect of zinc on the inhibition of human delta-aminolevulinic acid dehydratase by lead. Br J Ind Med. 1976 May;33(2):85–87. doi: 10.1136/oem.33.2.85. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DALLMAN P. R., SCHWARTZ H. C. DISTRIBUTION OF CYTOCHROME C AND MYOGLOBIN IN RATS WITH DIETARY IRON DEFICIENCY. Pediatrics. 1965 Apr;35:677–686. [PubMed] [Google Scholar]
  6. David O. J. Association between lower level lead concentrations and hyperactivity in children. Environ Health Perspect. 1974 May;7:17–25. doi: 10.1289/ehp.74717. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Degkwitz E., Walsch S., Dubberstein M., Winter J. Ascorbic acid and cytochromes. Ann N Y Acad Sci. 1975 Sep 30;258:201–208. doi: 10.1111/j.1749-6632.1975.tb29280.x. [DOI] [PubMed] [Google Scholar]
  8. Edgerton V. R., Bryant S. L., Gillespie C. A., Gardner G. W. Iron deficiency anemia and physical performance and activity of rats. J Nutr. 1972 Mar;102(3):381–399. doi: 10.1093/jn/102.3.381. [DOI] [PubMed] [Google Scholar]
  9. Fielding A. M., Hughes R. E. Changes in liver microsomal cytochrome P-450 induced by dietary proteins and lipid material. Biochem Pharmacol. 1976 Aug 15;25(16):1916–1917. doi: 10.1016/0006-2952(76)90200-8. [DOI] [PubMed] [Google Scholar]
  10. Fox M. R., Fry B. E., Jr Cadmium toxicity decreased by dietary ascorbic acid supplements. Science. 1970 Sep 4;169(3949):989–991. doi: 10.1126/science.169.3949.989. [DOI] [PubMed] [Google Scholar]
  11. Garber B. T., Wei E. Influence of dietary factors on the gastrointestinal absorption of lead. Toxicol Appl Pharmacol. 1974 Mar;27(3):685–691. doi: 10.1016/0041-008x(74)90048-9. [DOI] [PubMed] [Google Scholar]
  12. HEATH D. F., VANDEKAR M. TOXICITY AND METABOLISM OF DIELDRIN IN RATS. Br J Ind Med. 1964 Oct;21:269–279. doi: 10.1136/oem.21.4.269. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Keane W. T., Zavon M. R., Witherup S. H. Dieldrin poisoning in dogs: relation to obesity and treatment. Br J Ind Med. 1969 Oct;26(4):338–341. doi: 10.1136/oem.26.4.338. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Mahaffey K. R. Nutritional factors and susceptibility to lead toxicity. Environ Health Perspect. 1974 May;7:107–112. doi: 10.1289/ehp.747107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Maker H. S., Lehrer G. M., Silides D. J. The effect of lead on mouse brain development. Environ Res. 1975 Aug;10(1):76–91. doi: 10.1016/0013-9351(75)90075-4. [DOI] [PubMed] [Google Scholar]
  16. Marshall W. J., McLean A. E. The effect of nutrition and hormonal status on cytochrome P-450 and its induction. Biochem J. 1969 Dec;115(5):27P–28P. doi: 10.1042/bj1150027p. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Owen G., Lippman G. Nutritional status of infants and young children: U.S.A. Pediatr Clin North Am. 1977 Feb;24(1):211–227. doi: 10.1016/s0031-3955(16)33400-9. [DOI] [PubMed] [Google Scholar]
  18. Pollitt E., Leibel R. L. Iron deficiency and behavior. J Pediatr. 1976 Mar;88(3):372–381. doi: 10.1016/s0022-3476(76)80250-8. [DOI] [PubMed] [Google Scholar]
  19. Quarterman J., Morrison J. N., Humphries W. R. The effects of dietary lead content and food restriction on lead retention in rats. Environ Res. 1976 Oct;12(2):180–187. doi: 10.1016/0013-9351(76)90022-0. [DOI] [PubMed] [Google Scholar]
  20. Quarterman J., Morrison J. N. The effects of dietary calcium and phosphorus on the retention and excretion of lead in rats. Br J Nutr. 1975 Nov;34(3):351–362. doi: 10.1017/s0007114575000414. [DOI] [PubMed] [Google Scholar]
  21. Ragan H. A. Effects of iron deficiency on the absorption and distribution of lead and cadmium in rats. J Lab Clin Med. 1977 Oct;90(4):700–706. [PubMed] [Google Scholar]
  22. Shakman R. A. Nutritional influences on the toxicity of environmental pollutants: a review. Arch Environ Health. 1974 Feb;28(2):105–113. doi: 10.1080/00039896.1974.10666447. [DOI] [PubMed] [Google Scholar]
  23. Six K. M., Goyer R. A. Experimental enhancement of lead toxicity by low dietary calcium. J Lab Clin Med. 1970 Dec;76(6):933–942. [PubMed] [Google Scholar]
  24. Smith C. M., DeLuca H. F., Tanaka Y., Mahaffey K. R. Stimulation of lead absorption by vitamin D administration. J Nutr. 1978 May;108(5):843–847. doi: 10.1093/jn/108.5.843. [DOI] [PubMed] [Google Scholar]
  25. Weatherholtz W. M., Campbell T. C., Webb R. E. Effect of dietary protein levels on the toxicity and metabolism of heptachlor. J Nutr. 1969 May;98(1):90–94. doi: 10.1093/jn/98.1.90. [DOI] [PubMed] [Google Scholar]
  26. Ziegler E. E., Edwards B. B., Jensen R. L., Mahaffey K. R., Fomon S. J. Absorption and retention of lead by infants. Pediatr Res. 1978 Jan;12(1):29–34. doi: 10.1203/00006450-197801000-00008. [DOI] [PubMed] [Google Scholar]

Articles from Environmental Health Perspectives are provided here courtesy of National Institute of Environmental Health Sciences

RESOURCES