Abstract
A metabolic model for cadmium has been formulated in terms of a flow scheme for cadmium among eight body compartments. The mathematical description of the flow of cadmium between compartments consits of a number of differential equations, and the accumulation of cadmium may thus be calculated. Coeffcients for the flow of cadmium were estimated from empirical data both from animals and man. The modelling serves two main purposes: it provides a means of using present knowledge about metabolism in order to calculate expected accumulation in critical organs and other tissues and body fluids at certain intake levels and it makes it possible to define deficiencies in our present knowledge about metabolism. Data recently collected, partly as a result of considerations related to the model, have confirmed the assumptions of a very long biological half-time in other tissues and the small excretion of cadmium via bile.
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Selected References
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- Elinder C. G., Lind B., Kjellström T., Linnman L., Friberg L. Cadmium in kidney cortex, liver, and pancreas from Swedish autopsies. Estimation of biological half time in kidney cortex, considering calorie intake and smoking habits. Arch Environ Health. 1976 Nov-Dec;31(6):292–302. doi: 10.1080/00039896.1976.10667239. [DOI] [PubMed] [Google Scholar]
- Flanagan P. R., McLellan J. S., Haist J., Cherian G., Chamberlain M. J., Valberg L. S. Increased dietary cadmium absorption in mice and human subjects with iron deficiency. Gastroenterology. 1978 May;74(5 Pt 1):841–846. [PubMed] [Google Scholar]
- Kjellström T., Borg K., Lind B. Cadmium in feces as an estimator of daily cadmium intake in Sweden. Environ Res. 1978 Apr;15(2):242–251. doi: 10.1016/0013-9351(78)90101-9. [DOI] [PubMed] [Google Scholar]
- Kjellström T. Exposure and accumulation of cadmium in populations from Japan, the United States, and Sweden. Environ Health Perspect. 1979 Feb;28:169–197. doi: 10.1289/ehp.28-1637502. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kjellström T., Nordberg G. F. A kinetic model of cadmium metabolism in the human being. Environ Res. 1978 Jul;16(1-3):248–269. doi: 10.1016/0013-9351(78)90160-3. [DOI] [PubMed] [Google Scholar]
- Lauwerys R. R., Roels H. A., Buchet J. P., Bernard A., Stanescu D. Investigations on the lung and kidney function in workers exposed to cadmium. Environ Health Perspect. 1979 Feb;28:137–145. doi: 10.1289/ehp.7928137. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nordberg G. F., Robèrt K. H., Pannone M. K. Pancreatic and biliary excretion of cadmium in the rat. Acta Pharmacol Toxicol (Copenh) 1977 Jul;41(1):84–88. doi: 10.1111/j.1600-0773.1977.tb02127.x. [DOI] [PubMed] [Google Scholar]
- Nordberg M., Nordberg G. F. Distribution of metallothionein-bound cadmium and cadmium chloride in mice: preliminary studies. Environ Health Perspect. 1975 Dec;12:103–108. doi: 10.1289/ehp.7512103. [DOI] [PMC free article] [PubMed] [Google Scholar]