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. 2000 Aug;108(Suppl 4):615–623. doi: 10.1289/ehp.00108s4615

Current view of epidemiologic study designs for occupational and environmental lung diseases.

I B Tager 1
PMCID: PMC1637675  PMID: 10931780

Abstract

Epidemiologic studies long have played a role in the understanding of the effects of the general environment and various occupational exposures on the occurrence of acute and chronic diseases of the lung. This article is an overview of epidemiologic study designs that have particular relevance to studies of environmental and occupational lung disease. The application of times-series designs in the context of epidemiologic studies is discussed, as such designs have become widely used in studies of health effects ambient air pollution. The article emphasizes recent developments in the application of case-control study designs, many of which have had particular applications in epidemiologic studies related to environmental and occupational lung disease. These case-control designs offer efficient and valid alternatives for studies that in the past might have been conducted as more costly and time-consuming cohort studies.

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Selected References

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  1. Abbey D. E., Petersen F. F., Mills P. K., Kittle L. Chronic respiratory disease associated with long-term ambient concentrations of sulfates and other air pollutants. J Expo Anal Environ Epidemiol. 1993;3 (Suppl 1):99–115. [PubMed] [Google Scholar]
  2. Bateson T. F., Schwartz J. Control for seasonal variation and time trend in case-crossover studies of acute effects of environmental exposures. Epidemiology. 1999 Sep;10(5):539–544. [PubMed] [Google Scholar]
  3. Breslow N. E., Day N. E. Statistical methods in cancer research. Volume II--The design and analysis of cohort studies. IARC Sci Publ. 1987;(82):1–406. [PubMed] [Google Scholar]
  4. Breslow N. E. Statistics in epidemiology: the case-control study. J Am Stat Assoc. 1996 Mar;91(433):14–28. doi: 10.1080/01621459.1996.10476660. [DOI] [PubMed] [Google Scholar]
  5. Cain K. C., Breslow N. E. Logistic regression analysis and efficient design for two-stage studies. Am J Epidemiol. 1988 Dec;128(6):1198–1206. doi: 10.1093/oxfordjournals.aje.a115074. [DOI] [PubMed] [Google Scholar]
  6. DOLL R. Mortality from lung cancer in asbestos workers. Br J Ind Med. 1955 Apr;12(2):81–86. doi: 10.1136/oem.12.2.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Delfino R. J., Zeiger R. S., Seltzer J. M., Street D. H. Symptoms in pediatric asthmatics and air pollution: differences in effects by symptom severity, anti-inflammatory medication use and particulate averaging time. Environ Health Perspect. 1998 Nov;106(11):751–761. doi: 10.1289/ehp.98106751. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Dockery D. W., Pope C. A., 3rd Acute respiratory effects of particulate air pollution. Annu Rev Public Health. 1994;15:107–132. doi: 10.1146/annurev.pu.15.050194.000543. [DOI] [PubMed] [Google Scholar]
  9. Dockery D. W., Speizer F. E., Stram D. O., Ware J. H., Spengler J. D., Ferris B. G., Jr Effects of inhalable particles on respiratory health of children. Am Rev Respir Dis. 1989 Mar;139(3):587–594. doi: 10.1164/ajrccm/139.3.587. [DOI] [PubMed] [Google Scholar]
  10. Greenland S. A unified approach to the analysis of case-distribution (case-only) studies. Stat Med. 1999 Jan 15;18(1):1–15. doi: 10.1002/(sici)1097-0258(19990115)18:1<1::aid-sim961>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  11. Greenland S. Confounding and exposure trends in case-crossover and case-time-control designs. Epidemiology. 1996 May;7(3):231–239. doi: 10.1097/00001648-199605000-00003. [DOI] [PubMed] [Google Scholar]
  12. Greenland S. Interpretation and choice of effect measures in epidemiologic analyses. Am J Epidemiol. 1987 May;125(5):761–768. doi: 10.1093/oxfordjournals.aje.a114593. [DOI] [PubMed] [Google Scholar]
  13. Greenland S., Morgenstern H. Ecological bias, confounding, and effect modification. Int J Epidemiol. 1989 Mar;18(1):269–274. doi: 10.1093/ije/18.1.269. [DOI] [PubMed] [Google Scholar]
  14. Greenland S. The effect of misclassification in matched-pair case-control studies. Am J Epidemiol. 1982 Aug;116(2):402–406. doi: 10.1093/oxfordjournals.aje.a113424. [DOI] [PubMed] [Google Scholar]
  15. Greenland S., Thomas D. C. On the need for the rare disease assumption in case-control studies. Am J Epidemiol. 1982 Sep;116(3):547–553. doi: 10.1093/oxfordjournals.aje.a113439. [DOI] [PubMed] [Google Scholar]
  16. Künzli N., Tager I. B. The semi-individual study in air pollution epidemiology: a valid design as compared to ecologic studies. Environ Health Perspect. 1997 Oct;105(10):1078–1083. doi: 10.1289/ehp.105-1470382. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Langholz B., Clayton D. Sampling strategies in nested case-control studies. Environ Health Perspect. 1994 Nov;102 (Suppl 8):47–51. doi: 10.1289/ehp.94102s847. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Langholz B., Thomas D. C. Nested case-control and case-cohort methods of sampling from a cohort: a critical comparison. Am J Epidemiol. 1990 Jan;131(1):169–176. doi: 10.1093/oxfordjournals.aje.a115471. [DOI] [PubMed] [Google Scholar]
  19. Lee J. T., Schwartz J. Reanalysis of the effects of air pollution on daily mortality in Seoul, Korea: A case-crossover design. Environ Health Perspect. 1999 Aug;107(8):633–636. doi: 10.1289/ehp.99107633. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Liu L. J., Delfino R., Koutrakis P. Ozone exposure assessment in a southern California community. Environ Health Perspect. 1997 Jan;105(1):58–65. doi: 10.1289/ehp.9710558. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. MANTEL N., HAENSZEL W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 Apr;22(4):719–748. [PubMed] [Google Scholar]
  22. Maclure M. The case-crossover design: a method for studying transient effects on the risk of acute events. Am J Epidemiol. 1991 Jan 15;133(2):144–153. doi: 10.1093/oxfordjournals.aje.a115853. [DOI] [PubMed] [Google Scholar]
  23. Magnus P., Nafstad P., Oie L., Carlsen K. C., Becher G., Kongerud J., Carlsen K. H., Samuelsen S. O., Botten G., Bakketeig L. S. Exposure to nitrogen dioxide and the occurrence of bronchial obstruction in children below 2 years. Int J Epidemiol. 1998 Dec;27(6):995–999. doi: 10.1093/ije/27.6.995. [DOI] [PubMed] [Google Scholar]
  24. Marshall R. J., Jackson R. T. Analysis of case-crossover designs. Stat Med. 1993 Dec 30;12(24):2333–2341. doi: 10.1002/sim.4780122409. [DOI] [PubMed] [Google Scholar]
  25. McMichael A. J., Anderson H. R., Brunekreef B., Cohen A. J. Inappropriate use of daily mortality analyses to estimate longer-term mortality effects of air pollution. Int J Epidemiol. 1998 Jun;27(3):450–453. doi: 10.1093/ije/27.3.450. [DOI] [PubMed] [Google Scholar]
  26. Miettinen O. S. The "case-control" study: valid selection of subjects. J Chronic Dis. 1985;38(7):543–548. doi: 10.1016/0021-9681(85)90039-6. [DOI] [PubMed] [Google Scholar]
  27. Miettinen O. Design options in epidemiologic research. An update. Scand J Work Environ Health. 1982;8 (Suppl 1):7–14. [PubMed] [Google Scholar]
  28. Miettinen O. Estimability and estimation in case-referent studies. Am J Epidemiol. 1976 Feb;103(2):226–235. doi: 10.1093/oxfordjournals.aje.a112220. [DOI] [PubMed] [Google Scholar]
  29. Mittleman M. A., Maclure M., Robins J. M. Control sampling strategies for case-crossover studies: an assessment of relative efficiency. Am J Epidemiol. 1995 Jul 1;142(1):91–98. doi: 10.1093/oxfordjournals.aje.a117550. [DOI] [PubMed] [Google Scholar]
  30. Morgenstern H. Uses of ecologic analysis in epidemiologic research. Am J Public Health. 1982 Dec;72(12):1336–1344. doi: 10.2105/ajph.72.12.1336. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Neas L. M., Dockery D. W., Burge H., Koutrakis P., Speizer F. E. Fungus spores, air pollutants, and other determinants of peak expiratory flow rate in children. Am J Epidemiol. 1996 Apr 15;143(8):797–807. doi: 10.1093/oxfordjournals.aje.a008818. [DOI] [PubMed] [Google Scholar]
  32. Neas L. M., Dockery D. W., Koutrakis P., Tollerud D. J., Speizer F. E. The association of ambient air pollution with twice daily peak expiratory flow rate measurements in children. Am J Epidemiol. 1995 Jan 15;141(2):111–122. doi: 10.1093/oxfordjournals.aje.a117399. [DOI] [PubMed] [Google Scholar]
  33. Neas L. M., Schwartz J., Dockery D. A case-crossover analysis of air pollution and mortality in Philadelphia. Environ Health Perspect. 1999 Aug;107(8):629–631. doi: 10.1289/ehp.99107629. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Peters A., Dockery D. W., Heinrich J., Wichmann H. E. Medication use modifies the health effects of particulate sulfate air pollution in children with asthma. Environ Health Perspect. 1997 Apr;105(4):430–435. doi: 10.1289/ehp.97105430. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Peters J. M., Avol E., Gauderman W. J., Linn W. S., Navidi W., London S. J., Margolis H., Rappaport E., Vora H., Gong H., Jr A study of twelve Southern California communities with differing levels and types of air pollution. II. Effects on pulmonary function. Am J Respir Crit Care Med. 1999 Mar;159(3):768–775. doi: 10.1164/ajrccm.159.3.9804144. [DOI] [PubMed] [Google Scholar]
  36. Peters J. M., Avol E., Navidi W., London S. J., Gauderman W. J., Lurmann F., Linn W. S., Margolis H., Rappaport E., Gong H. A study of twelve Southern California communities with differing levels and types of air pollution. I. Prevalence of respiratory morbidity. Am J Respir Crit Care Med. 1999 Mar;159(3):760–767. doi: 10.1164/ajrccm.159.3.9804143. [DOI] [PubMed] [Google Scholar]
  37. Piantadosi S., Byar D. P., Green S. B. The ecological fallacy. Am J Epidemiol. 1988 May;127(5):893–904. doi: 10.1093/oxfordjournals.aje.a114892. [DOI] [PubMed] [Google Scholar]
  38. Reilly M. Optimal sampling strategies for two-stage studies. Am J Epidemiol. 1996 Jan 1;143(1):92–100. doi: 10.1093/oxfordjournals.aje.a008662. [DOI] [PubMed] [Google Scholar]
  39. Samet J. M., Muñoz A. Perspective: cohort studies. Epidemiol Rev. 1998;20(1):135–136. doi: 10.1093/oxfordjournals.epirev.a017968. [DOI] [PubMed] [Google Scholar]
  40. Schwartz J. Lung function and chronic exposure to air pollution: a cross-sectional analysis of NHANES II. Environ Res. 1989 Dec;50(2):309–321. doi: 10.1016/s0013-9351(89)80012-x. [DOI] [PubMed] [Google Scholar]
  41. Schwartz J., Spix C., Touloumi G., Bachárová L., Barumamdzadeh T., le Tertre A., Piekarksi T., Ponce de Leon A., Pönkä A., Rossi G. Methodological issues in studies of air pollution and daily counts of deaths or hospital admissions. J Epidemiol Community Health. 1996 Apr;50 (Suppl 1):S3–11. doi: 10.1136/jech.50.suppl_1.s3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Schwartz S. The fallacy of the ecological fallacy: the potential misuse of a concept and the consequences. Am J Public Health. 1994 May;84(5):819–824. doi: 10.2105/ajph.84.5.819. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Stern B. R., Raizenne M. E., Burnett R. T., Jones L., Kearney J., Franklin C. A. Air pollution and childhood respiratory health: exposure to sulfate and ozone in 10 Canadian rural communities. Environ Res. 1994 Aug;66(2):125–142. doi: 10.1006/enrs.1994.1049. [DOI] [PubMed] [Google Scholar]
  44. Susser M. The logic in ecological: I. The logic of analysis. Am J Public Health. 1994 May;84(5):825–829. doi: 10.2105/ajph.84.5.825. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Tager I. B. Outcomes in cohort studies. Epidemiol Rev. 1998;20(1):15–28. doi: 10.1093/oxfordjournals.epirev.a017969. [DOI] [PubMed] [Google Scholar]
  46. Thomas D. New techniques for the analysis of cohort studies. Epidemiol Rev. 1998;20(1):122–134. doi: 10.1093/oxfordjournals.epirev.a017967. [DOI] [PubMed] [Google Scholar]
  47. Thomas D., Stram D., Dwyer J. Exposure measurement error: influence on exposure-disease. Relationships and methods of correction. Annu Rev Public Health. 1993;14:69–93. doi: 10.1146/annurev.pu.14.050193.000441. [DOI] [PubMed] [Google Scholar]
  48. Wacholder S., McLaughlin J. K., Silverman D. T., Mandel J. S. Selection of controls in case-control studies. I. Principles. Am J Epidemiol. 1992 May 1;135(9):1019–1028. doi: 10.1093/oxfordjournals.aje.a116396. [DOI] [PubMed] [Google Scholar]
  49. Wacholder S., Silverman D. T., McLaughlin J. K., Mandel J. S. Selection of controls in case-control studies. II. Types of controls. Am J Epidemiol. 1992 May 1;135(9):1029–1041. doi: 10.1093/oxfordjournals.aje.a116397. [DOI] [PubMed] [Google Scholar]
  50. Wacholder S., Silverman D. T., McLaughlin J. K., Mandel J. S. Selection of controls in case-control studies. III. Design options. Am J Epidemiol. 1992 May 1;135(9):1042–1050. doi: 10.1093/oxfordjournals.aje.a116398. [DOI] [PubMed] [Google Scholar]
  51. Willich S. N., Lewis M., Löwel H., Arntz H. R., Schubert F., Schröder R. Physical exertion as a trigger of acute myocardial infarction. Triggers and Mechanisms of Myocardial Infarction Study Group. N Engl J Med. 1993 Dec 2;329(23):1684–1690. doi: 10.1056/NEJM199312023292302. [DOI] [PubMed] [Google Scholar]
  52. Zaffanella L. E., Savitz D. A., Greenland S., Ebi K. L. The residential case-specular method to study wire codes, magnetic fields, and disease. Epidemiology. 1998 Jan;9(1):16–20. [PubMed] [Google Scholar]
  53. Zeger S. L., Dominici F., Samet J. Harvesting-resistant estimates of air pollution effects on mortality. Epidemiology. 1999 Mar;10(2):171–175. [PubMed] [Google Scholar]
  54. Zhao L. P., Lipsitz S. Designs and analysis of two-stage studies. Stat Med. 1992 Apr;11(6):769–782. doi: 10.1002/sim.4780110608. [DOI] [PubMed] [Google Scholar]

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