Abstract
Rats were given a single dose of toxaphene (120 mg/kg equilavent to 1/2 LD50) and sacrificed at 1, 5, and 15 days. No alterations of levels of pyruvic or lactic acid in blood plasma were observed. In a second experiment, rats were given 2.4 mg/kg daily and sacrificed at 1, 3, and 6 months, and again no alterations of pyruvic or lactic acid levels were found. It is concluded that observed alterations of the activity of lactic acid dehydrogenase induced by toxaphene do not give rise to physiological changes in unstressed rats.
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Selected References
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