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. 1979 Oct;32:53–58. doi: 10.1289/ehp.793253

Developing clues to environmental cancer: a stepwise approach with the use of cancer mortality data.

W J Blot, J F Fraumeni Jr, T J Mason, R N Hoover
PMCID: PMC1637941  PMID: 540606

Abstract

Clues to environmental determinants can often be derived from the patterns of mortality from cancer. This review focuses on the stepwise approach of using cancer mortality maps, supplemented by correlation studies linking mortality rates with demographic and industrial data at the county level, to generate hypotheses to cancer etiology which can then be pursued by analytical epidemiological studies. Advantages and limitations of this approach and its application in the study of lung cancer in the United States are described.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Acheson E. D., Cowdell R. H., Hadfield E., Macbeth R. G. Nasal cancer in woodworkers in the furniture industry. Br Med J. 1968 Jun 8;2(5605):587–596. doi: 10.1136/bmj.2.5605.587. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Acheson E. D., Hadfield E. H., Macbeth R. G. Carcinoma of the nasal cavity and accessory sinuses in woodworkers. Lancet. 1967 Feb 11;1(7485):311–312. doi: 10.1016/s0140-6736(67)91243-3. [DOI] [PubMed] [Google Scholar]
  3. Blot W. J., Fraumeni J. F., Jr Arsenical air pollution and lung cancer. Lancet. 1975 Jul 26;2(7926):142–144. doi: 10.1016/s0140-6736(75)90054-9. [DOI] [PubMed] [Google Scholar]
  4. Blot W. J., Fraumeni J. F., Jr Geographic patterns of bladder cancer in the United States. J Natl Cancer Inst. 1978 Oct;61(4):1017–1023. [PubMed] [Google Scholar]
  5. Blot W. J., Fraumeni J. F., Jr Geographic patterns of lung cancer: industrial correlations. Am J Epidemiol. 1976 Jun;103(6):539–550. doi: 10.1093/oxfordjournals.aje.a112258. [DOI] [PubMed] [Google Scholar]
  6. Blot W. J., Harrington J. M., Toledo A., Hoover R., Heath C. W., Jr, Fraumeni J. F., Jr Lung cancer after employment in shipyards during World War II. N Engl J Med. 1978 Sep 21;299(12):620–624. doi: 10.1056/NEJM197809212991202. [DOI] [PubMed] [Google Scholar]
  7. Blot W. J., Stone B. J., Fraumeni J. F., Jr, Morris L. E. Cancer mortality in U.S. counties with shipyard industries during World War II. Environ Res. 1979 Apr;18(2):281–290. doi: 10.1016/0013-9351(79)90105-1. [DOI] [PubMed] [Google Scholar]
  8. Brinton L. A., Blot W. J., Stone B. J., Fraumeni J. F., Jr A death certificate analysis of nasal cancer among furniture workers in North Carolina. Cancer Res. 1977 Oct;37(10):3473–3474. [PubMed] [Google Scholar]
  9. Brinton L. A., Stone B. J., Blot W. J., Fraumeni J. F., Jr Nasal cancer in U.S. furniture industry countries. Lancet. 1976 Sep 18;2(7986):628–628. doi: 10.1016/s0140-6736(76)90691-7. [DOI] [PubMed] [Google Scholar]
  10. CASE R. A., HOSKER M. E., McDONALD D. B., PEARSON J. T. Tumours of the urinary bladder in workmen engaged in the manufacture and use of certain dyestuff intermediates in the British chemical industry. I. The role of aniline, benzidine, alpha-naphthylamine, and beta-naphthylamine. Br J Ind Med. 1954 Apr;11(2):75–104. doi: 10.1136/oem.11.2.75. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Clayson D. B. Occupational bladder cancer. Prev Med. 1976 Jun;5(2):228–244. doi: 10.1016/0091-7435(76)90042-6. [DOI] [PubMed] [Google Scholar]
  12. Creech J. L., Jr, Johnson M. N. Angiosarcoma of liver in the manufacture of polyvinyl chloride. J Occup Med. 1974 Mar;16(3):150–151. [PubMed] [Google Scholar]
  13. Harrington J. M., Blot W. J., Hoover R. N., Housworth W. J., Heath C. W., Jr, Fraumeni J. F., Jr Lung cancer in coastal Georgia: a death certificate analysis of occupation: brief communication. J Natl Cancer Inst. 1978 Feb;60(2):295–298. doi: 10.1093/jnci/60.2.295. [DOI] [PubMed] [Google Scholar]
  14. Hoover R., Fraumeni J. F., Jr Cancer mortality in U.S. counties with chemical industries. Environ Res. 1975 Apr;9(2):196–207. doi: 10.1016/0013-9351(75)90064-x. [DOI] [PubMed] [Google Scholar]
  15. MACBETH R. MALIGNANT DISEASE OF THE PARANASAL SINUSES. J Laryngol Otol. 1965 Jul;79:592–612. doi: 10.1017/s0022215100064112. [DOI] [PubMed] [Google Scholar]
  16. Selikoff I. J., Hammond E. C. Asbestos-associated disease in United States shipyards. CA Cancer J Clin. 1978 Mar-Apr;28(2):87–99. doi: 10.3322/canjclin.28.2.87. [DOI] [PubMed] [Google Scholar]

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