Abstract
The in vitro activity of voriconazole was compared with that of itraconazole. Eighty-six isolates of pathogenic molds belonging to 23 species were tested by an agar dilution method in High Resolution medium. Voriconazole was more active than itraconazole against a number of hyaline molds, including several Fusarium spp. and Scedosporium prolificans. Voriconazole and itraconazole showed comparable good activity against several hyaline molds, including Penicillium marneffei and Scedosporium apiospermum, and a number of dematiaceous molds, including Bipolaris australiensis, Cladophialophora bantiana, several Exophiala spp., and several Fonsecaea spp. Our results suggest that voriconazole could be effective against a wide range of mold infections in humans.
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Selected References
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- Espinel-Ingroff A., Dawson K., Pfaller M., Anaissie E., Breslin B., Dixon D., Fothergill A., Paetznick V., Peter J., Rinaldi M. Comparative and collaborative evaluation of standardization of antifungal susceptibility testing for filamentous fungi. Antimicrob Agents Chemother. 1995 Feb;39(2):314–319. doi: 10.1128/aac.39.2.314. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gamis A. S., Gudnason T., Giebink G. S., Ramsay N. K. Disseminated infection with Fusarium in recipients of bone marrow transplants. Rev Infect Dis. 1991 Nov-Dec;13(6):1077–1088. doi: 10.1093/clinids/13.6.1077. [DOI] [PubMed] [Google Scholar]
- Gehrt A., Peter J., Pizzo P. A., Walsh T. J. Effect of increasing inoculum sizes of pathogenic filamentous fungi on MICs of antifungal agents by broth microdilution method. J Clin Microbiol. 1995 May;33(5):1302–1307. doi: 10.1128/jcm.33.5.1302-1307.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
- George D., Miniter P., Andriole V. T. Efficacy of UK-109496, a new azole antifungal agent, in an experimental model of invasive aspergillosis. Antimicrob Agents Chemother. 1996 Jan;40(1):86–91. doi: 10.1128/aac.40.1.86. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hopwood V., Evans E. G., Matthews J., Denning D. W. Scedosporium prolificans, a multi-resistant fungus, from a U.K. AIDS patient. J Infect. 1995 Mar;30(2):153–155. doi: 10.1016/s0163-4453(95)80011-5. [DOI] [PubMed] [Google Scholar]
- Lutwick L. I., Galgiani J. N., Johnson R. H., Stevens D. A. Visceral fungal infections due to Petriellidium boydii (allescheria boydii). In vitro drug sensitivity studies. Am J Med. 1976 Nov;61(5):632–640. doi: 10.1016/0002-9343(76)90141-8. [DOI] [PubMed] [Google Scholar]
- Rodríguez-Tudela J. L., Martínez-Suárez J. V., Dronda F., Laguna F., Chaves F., Valencia E. Correlation of in-vitro susceptibility test results with clinical response: a study of azole therapy in AIDS patients. J Antimicrob Chemother. 1995 Jun;35(6):793–804. doi: 10.1093/jac/35.6.793. [DOI] [PubMed] [Google Scholar]
- Valentin A., Le Guennec R., Rodriguez E., Reynes J., Mallie M., Bastide J. M. Comparative resistance of Candida albicans clinical isolates to fluconazole and itraconazole in vitro and in vivo in a murine model. Antimicrob Agents Chemother. 1996 Jun;40(6):1342–1345. doi: 10.1128/aac.40.6.1342. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Velez J. D., Allendoerfer R., Luther M., Rinaldi M. G., Graybill J. R. Correlation of in vitro azole susceptibility with in vivo response in a murine model of cryptococcal meningitis. J Infect Dis. 1993 Aug;168(2):508–510. doi: 10.1093/infdis/168.2.508. [DOI] [PubMed] [Google Scholar]