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. 1997 Apr;41(4):847–849. doi: 10.1128/aac.41.4.847

Bactericidal activity of DU-6859a compared to activities of three quinolones, three beta-lactams, clindamycin, and metronidazole against anaerobes as determined by time-kill methodology.

S K Spangler 1, M R Jacobs 1, P C Appelbaum 1
PMCID: PMC163808  PMID: 9087503

Abstract

The activities of DU-6859a, ciprofloxacin, levofloxacin, sparfloxacin, piperacillin, piperacillin-tazobactam, imipenem, clindamycin, and metronidazole against 11 anaerobes were tested by the broth microdilution and time-kill methods. DU-6859a was the most active drug tested (broth microdilution MICs, 0.06 to 0.5 microg/ml), followed by imipenem (MICs, 0.002 to 4.0 microg/ml). Broth macrodilution MICs were within 3 (but usually 1) dilutions of the broth microdilution MICs. All compounds were bactericidal at the MIC after 48 h; after 24 h, 90% killing was shown for all strains when the compounds were used at four times the MIC. DU-6859a at < or = 0.5 microg/ml was bactericidal after 48 h.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Appelbaum P. C. Quinolone activity against anaerobes: microbiological aspects. Drugs. 1995;49 (Suppl 2):76–80. doi: 10.2165/00003495-199500492-00012. [DOI] [PubMed] [Google Scholar]
  2. Jacobs M. R., Spangler S. K., Appelbaum P. C. beta-Lactamase production and susceptibility of US and European anaerobic gram-negative bacilli to beta-lactams and other agents. Eur J Clin Microbiol Infect Dis. 1992 Nov;11(11):1081–1093. doi: 10.1007/BF01967803. [DOI] [PubMed] [Google Scholar]
  3. Jolley A., Andrews J. M., Brenwald N., Wise R. The in-vitro activity of a new highly active quinolone, DU-6859a. J Antimicrob Chemother. 1993 Nov;32(5):757–763. doi: 10.1093/jac/32.5.757. [DOI] [PubMed] [Google Scholar]
  4. Korten V., Tomayko J. F., Murray B. E. Comparative in vitro activity of DU-6859a, a new fluoroquinolone agent, against gram-positive cocci. Antimicrob Agents Chemother. 1994 Mar;38(3):611–615. doi: 10.1128/aac.38.3.611. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Marshall S. A., Jones R. N. In vitro activity of DU-6859a, a new fluorocyclopropyl quinolone. Antimicrob Agents Chemother. 1993 Dec;37(12):2747–2753. doi: 10.1128/aac.37.12.2747. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Marshall S. A., Jones R. N., Murray P. R., Washington J. A., Allen S. D., Gerlach E. H., Erwin M. E. In-vitro comparison of DU-6859a, a novel fluoroquinolone, with other quinolones and oral cephalosporins tested against 5086 recent clinical isolates. J Antimicrob Chemother. 1993 Dec;32(6):877–884. doi: 10.1093/jac/32.6.877. [DOI] [PubMed] [Google Scholar]
  7. Nakane T., Iyobe S., Sato K., Mitsuhashi S. In vitro antibacterial activity of DU-6859a, a new fluoroquinolone. Antimicrob Agents Chemother. 1995 Dec;39(12):2822–2826. doi: 10.1128/aac.39.12.2822. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Pankuch G. A., Jacobs M. R., Rittenhouse S. F., Appelbaum P. C. Susceptibilities of 123 strains of Xanthomonas maltophilia to eight beta-lactams (including beta-lactam-beta-lactamase inhibitor combinations) and ciprofloxacin tested by five methods. Antimicrob Agents Chemother. 1994 Oct;38(10):2317–2322. doi: 10.1128/aac.38.10.2317. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Sato K., Hoshino K., Tanaka M., Hayakawa I., Osada Y. Antimicrobial activity of DU-6859, a new potent fluoroquinolone, against clinical isolates. Antimicrob Agents Chemother. 1992 Jul;36(7):1491–1498. doi: 10.1128/aac.36.7.1491. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Spangler S. K., Jacobs M. R., Appelbaum P. C. Effect of CO2 on susceptibilities of anaerobes to erythromycin, azithromycin, clarithromycin, and roxithromycin. Antimicrob Agents Chemother. 1994 Feb;38(2):211–216. doi: 10.1128/aac.38.2.211. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Visalli M. A., Jacobs M. R., Appelbaum P. C. MIC and time-kill study of activities of DU-6859a, ciprofloxacin, levofloxacin, sparfloxacin, cefotaxime, imipenem, and vancomycin against nine penicillin-susceptible and -resistant pneumococci. Antimicrob Agents Chemother. 1996 Feb;40(2):362–366. doi: 10.1128/aac.40.2.362. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Wexler H. M., Molitoris E., Reeves D., Finegold S. M. In vitro activity of DU-6859a against anaerobic bacteria. Antimicrob Agents Chemother. 1994 Oct;38(10):2504–2509. doi: 10.1128/aac.38.10.2504. [DOI] [PMC free article] [PubMed] [Google Scholar]

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