Abstract
Measles-virus-specific IgG was measured in the serum of 100 patients who had presented with optic neuritis (ON) during 1960-74. When reviewed 41 of them were found to have developed definite symptoms and signs of multiple sclerosis (MS), their serum containing significantly higher titres of the antibody than sera from either the rest of the patients or a group of normal healthy controls. In a few patients from whom cerebrospinal fluid (CSF) was obtained in the acute phase of ON, titres of measles IgG in the serum was higher in those in whom the antibody was detected in the CSF than the serum of patients without CSF antibody.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ADAMS J. M., IMAGAWA D. T. Measles antibodies in multiple sclerosis. Proc Soc Exp Biol Med. 1962 Dec;111:562–566. doi: 10.3181/00379727-111-27855. [DOI] [PubMed] [Google Scholar]
- Brody J. A., Sever J. L., Edgar A., McNew J. Measles antibody titers of multiple sclerosis patients and their siblings. Neurology. 1972 May;22(5):492–499. doi: 10.1212/wnl.22.5.492. [DOI] [PubMed] [Google Scholar]
- Haire M., Fraser K. B., Millar J. H. Measles and other virus-specific immunoglobulins in multiple sclerosis. Br Med J. 1973 Sep 22;3(5881):612–615. doi: 10.1136/bmj.3.5881.612. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Haire M., Fraser K. B., Millar J. H. Virus-specific immunoglobulins in multiple sclerosis. Clin Exp Immunol. 1973 Jul;14(3):409–416. [PMC free article] [PubMed] [Google Scholar]
- Haire M., Fraser K. B., Millar J. H. Virus-specific immunoglobulins in multiple sclerosis. Clin Exp Immunol. 1973 Jul;14(3):409–416. [PMC free article] [PubMed] [Google Scholar]
- Haire M., Millar J. H., Merrett J. D. Measles virus-specific IgG in cerebrospinal fluid in multiple sclerosis. Br Med J. 1974 Oct 26;4(5938):192–193. doi: 10.1136/bmj.4.5938.192. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Link H., Müller R. Immunoglobulins in multiple sclerosis and infections of the nervous system. Arch Neurol. 1971 Oct;25(4):326–344. doi: 10.1001/archneur.1971.00490040052007. [DOI] [PubMed] [Google Scholar]
- Link H., Norrby E., Olsson J. E. Immunoglobulins and measles antibodies in optic neuritis. N Engl J Med. 1973 Nov 22;289(21):1103–1107. doi: 10.1056/NEJM197311222892102. [DOI] [PubMed] [Google Scholar]
- Nikoskelainen E., Nikoskelainen J., Salmi A. A., Halonen P. E. Virus antibody levels in serum specimens from patients with optic neuritis and from matched controls;. Acta Neurol Scand. 1975 May;51(5):333–346. doi: 10.1111/j.1600-0404.1975.tb01374.x. [DOI] [PubMed] [Google Scholar]
- Nikoskelainen E., Nikoskelainen J., Salmi A. A., Halonen P. E. Virus antibody levels in the cerebrospinal fluid from patients with optic neuritis. Acta Neurol Scand. 1975 May;51(5):347–364. doi: 10.1111/j.1600-0404.1975.tb01375.x. [DOI] [PubMed] [Google Scholar]
- Salmi A. A., Norrby E., Panelius M. Identification of different measles virus-specific antibodies in the serum and cerebrospinal fluid from patients with subacute sclerosing pancencephalitis and multiple sclerosis. Infect Immun. 1972 Sep;6(3):248–254. doi: 10.1128/iai.6.3.248-254.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]