Abstract
The treatment of children with rhabdomyosarcoma by a combination of surgery, radiotherapy, and chemotherapy has resulted in an improved disease-free survival time. Of 11 children with regional disease eight (72%) remained well, with no evidence of disease, four to 36 months after diagnosis. Chemotherapy for one year with vincristine, actinomycin D, and cyclophosphamide was well tolerated during and after radical radiotherapy and surgery. The natural history of this malignancy has been altered in these patients when compared with that in a historical group of 17 children, only two of whom remain alive. There has been no serious short-term toxicity so far.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Donaldson S. S., Castro J. R., Wilbur J. R., Jesse R. H., Jr Rhabdomyosarcoma of head and neck in children. Combination treatment by surgery, irradiation, and chemotherapy. Cancer. 1973 Jan;31(1):26–35. doi: 10.1002/1097-0142(197301)31:1<26::aid-cncr2820310105>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
- Heyn R. M., Holland R., Newton W. A., Jr, Tefft M., Breslow N., Hartmann J. R. The role of combined chemotherapy in the treatment of rhabdomyosarcoma in children. Cancer. 1974 Dec;34(6):2128–2142. doi: 10.1002/1097-0142(197412)34:6<2128::aid-cncr2820340638>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
- Pratt C. B., Hustu H. O., Fleming I. D., Pinkel D. Coordinated treatment of childhood rhabdomyosarcoma with surgery, radiotherapy, and combination chemotherapy. Cancer Res. 1972 Mar;32(3):606–610. [PubMed] [Google Scholar]
- Pratt C. B. Response of childhood rhabdomyosarcoma to combination chemotherapy. J Pediatr. 1969 May;74(5):791–794. doi: 10.1016/s0022-3476(69)80145-9. [DOI] [PubMed] [Google Scholar]