Skip to main content
NCBI home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1997 May;41(5):1175–1177. doi: 10.1128/aac.41.5.1175

Lack of ability of ciprofloxacin-rifampin prophylaxis to decrease infection-related morbidity in neutropenic patients given cytotoxic therapy and peripheral blood stem cell transplants.

M Hidalgo 1, J Hornedo 1, C Lumbreras 1, J M Trigo 1, C Gómez 1, S Perea 1, A Ruiz 1, R Hitt 1, H Cortés-Funes 1
PMCID: PMC163876  PMID: 9145895

Abstract

We compared ciprofloxacin alone with ciprofloxacin plus rifampin (C + R) as a prophylactic antibacterial regimen for 40 patients with solid tumors treated with high-dose chemotherapy and autologous stem cell transplantation support. No differences were found between groups in the time elapsed to the onset of fever, incidence of febrile episodes, amphotericin B use, and length of hospital stay. However, C + R combination prophylaxis significantly reduced the incidence of gram-positive bacteremia (five versus zero episodes) but was associated with a higher incidence of drug-related side effects.

Full Text

The Full Text of this article is available as a PDF (169.2 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Attal M., Schlaifer D., Rubie H., Huguet F., Charlet J. P., Bloom E., Lemozy J., Massip P., Pris J., Laurent G. Prevention of gram-positive infections after bone marrow transplantation by systemic vancomycin: a prospective, randomized trial. J Clin Oncol. 1991 May;9(5):865–870. doi: 10.1200/JCO.1991.9.5.865. [DOI] [PubMed] [Google Scholar]
  2. Awada A., van der Auwera P., Meunier F., Daneau D., Klastersky J. Streptococcal and enterococcal bacteremia in patients with cancer. Clin Infect Dis. 1992 Jul;15(1):33–48. doi: 10.1093/clinids/15.1.33. [DOI] [PubMed] [Google Scholar]
  3. Bochud P. Y., Eggiman P., Calandra T., Van Melle G., Saghafi L., Francioli P. Bacteremia due to viridans streptococcus in neutropenic patients with cancer: clinical spectrum and risk factors. Clin Infect Dis. 1994 Jan;18(1):25–31. doi: 10.1093/clinids/18.1.25. [DOI] [PubMed] [Google Scholar]
  4. Bow E. J., Mandell L. A., Louie T. J., Feld R., Palmer M., Zee B., Pater J. Quinolone-based antibacterial chemoprophylaxis in neutropenic patients: effect of augmented gram-positive activity on infectious morbidity. National Cancer Institute of Canada Clinical Trials Group. Ann Intern Med. 1996 Aug 1;125(3):183–190. doi: 10.7326/0003-4819-125-3-199608010-00004. [DOI] [PubMed] [Google Scholar]
  5. Burden A. D., Oppenheim B. A., Crowther D., Howell A., Morgenstern G. R., Scarffe J. H., Thatcher N. Viridans streptococcal bacteraemia in patients with haematological and solid malignancies. Eur J Cancer. 1991;27(4):409–411. doi: 10.1016/0277-5379(91)90373-l. [DOI] [PubMed] [Google Scholar]
  6. Elting L. S., Bodey G. P., Keefe B. H. Septicemia and shock syndrome due to viridans streptococci: a case-control study of predisposing factors. Clin Infect Dis. 1992 Jun;14(6):1201–1207. doi: 10.1093/clinids/14.6.1201. [DOI] [PubMed] [Google Scholar]
  7. Gilbert C., Meisenberg B., Vredenburgh J., Ross M., Hussein A., Perfect J., Peters W. P. Sequential prophylactic oral and empiric once-daily parenteral antibiotics for neutropenia and fever after high-dose chemotherapy and autologous bone marrow support. J Clin Oncol. 1994 May;12(5):1005–1011. doi: 10.1200/JCO.1994.12.5.1005. [DOI] [PubMed] [Google Scholar]
  8. Hughes W. T., Armstrong D., Bodey G. P., Feld R., Mandell G. L., Meyers J. D., Pizzo P. A., Schimpff S. C., Shenep J. L., Wade J. C. From the Infectious Diseases Society of America. Guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever. J Infect Dis. 1990 Mar;161(3):381–396. doi: 10.1093/infdis/161.3.381. [DOI] [PubMed] [Google Scholar]
  9. Karp J. E., Merz W. G., Hendricksen C., Laughon B., Redden T., Bamberger B. J., Bartlett J. G., Saral R., Burke P. J. Oral norfloxacin for prevention of gram-negative bacterial infections in patients with acute leukemia and granulocytopenia. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1987 Jan;106(1):1–7. doi: 10.7326/0003-4819-106-1-1. [DOI] [PubMed] [Google Scholar]
  10. Kern W. V., Hay B., Kern P., Marre R., Arnold R. A randomized trial of roxithromycin in patients with acute leukemia and bone marrow transplant recipients receiving fluoroquinolone prophylaxis. Antimicrob Agents Chemother. 1994 Mar;38(3):465–472. doi: 10.1128/aac.38.3.465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kern W., Kurrle E., Schmeiser T. Streptococcal bacteremia in adult patients with leukemia undergoing aggressive chemotherapy. A review of 55 cases. Infection. 1990 May-Jun;18(3):138–145. doi: 10.1007/BF01642101. [DOI] [PubMed] [Google Scholar]
  12. Kilton L. J., Fossieck B. E., Jr, Cohen M. H., Parker R. H. Bacteremia due to gram-positive cocci in patients with neoplastic disease. Am J Med. 1979 Apr;66(4):596–602. doi: 10.1016/0002-9343(79)91169-0. [DOI] [PubMed] [Google Scholar]
  13. Lew M. A., Kehoe K., Ritz J., Antman K. H., Nadler L., Kalish L. A., Finberg R. Ciprofloxacin versus trimethoprim/sulfamethoxazole for prophylaxis of bacterial infections in bone marrow transplant recipients: a randomized, controlled trial. J Clin Oncol. 1995 Jan;13(1):239–250. doi: 10.1200/JCO.1995.13.1.239. [DOI] [PubMed] [Google Scholar]
  14. Lew M. A., Kehoe K., Ritz J., Antman K. H., Nadler L., Takvorian T., Mayer R., Kalish L., Finberg R. Prophylaxis of bacterial infections with ciprofloxacin in patients undergoing bone marrow transplantation. Transplantation. 1991 Mar;51(3):630–636. doi: 10.1097/00007890-199103000-00017. [DOI] [PubMed] [Google Scholar]
  15. Martino P., Micozzi A., Gentile G., Raccah R., Girmenia C., Mandelli F. Piperacillin plus amikacin vs. piperacillin plus amikacin plus teicoplanin for empirical treatment of febrile episodes in neutropenic patients receiving quinolone prophylaxis. Clin Infect Dis. 1992 Aug;15(2):290–294. doi: 10.1093/clinids/15.2.290. [DOI] [PubMed] [Google Scholar]
  16. Villablanca J. G., Steiner M., Kersey J., Ramsay N. K., Ferrieri P., Haake R., Weisdorf D. The clinical spectrum of infections with viridans streptococci in bone marrow transplant patients. Bone Marrow Transplant. 1990 Jun;5(6):387–393. [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES