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. 1997 May;41(5):1186–1189. doi: 10.1128/aac.41.5.1186

Trovafloxacin in treatment of rabbits with experimental meningitis caused by high-level penicillin-resistant Streptococcus pneumoniae.

Y S Kim 1, Q Liu 1, L L Chow 1, M G Täuber 1
PMCID: PMC163879  PMID: 9145898

Abstract

The fluoroquinolone trovafloxacin was bactericidal (0.47 +/- 0.23 delta log10 CFU/ml x h after 10 mg/kg of body weight and 0.78 +/- 0.15 delta log10 CFU/ml x h after 30 mg/kg) in the treatment of experimental meningitis caused by a highly penicillin-resistant (MIC and minimum bactericidal concentration = 4 and 4 microg/ml) strain of Streptococcus pneumoniae. Combinations with ampicillin and rifampin were indifferent compared to single drugs.

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Selected References

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  1. Barnes D. M., Whittier S., Gilligan P. H., Soares S., Tomasz A., Henderson F. W. Transmission of multidrug-resistant serotype 23F Streptococcus pneumoniae in group day care: evidence suggesting capsular transformation of the resistant strain in vivo. J Infect Dis. 1995 Apr;171(4):890–896. doi: 10.1093/infdis/171.4.890. [DOI] [PubMed] [Google Scholar]
  2. Beam T. R. Vancomycin therapy of experimental pneumococcal meningitis caused by penicillin-sensitive and resistant strains. J Antimicrob Chemother. 1981 Jan;7(1):89–99. doi: 10.1093/jac/7.1.89. [DOI] [PubMed] [Google Scholar]
  3. Breiman R. F., Butler J. C., Tenover F. C., Elliott J. A., Facklam R. R. Emergence of drug-resistant pneumococcal infections in the United States. JAMA. 1994 Jun 15;271(23):1831–1835. [PubMed] [Google Scholar]
  4. Dacey R. G., Sande M. A. Effect of probenecid on cerebrospinal fluid concentrations of penicillin and cephalosporin derivatives. Antimicrob Agents Chemother. 1974 Oct;6(4):437–441. doi: 10.1128/aac.6.4.437. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Doit C. P., Bonacorsi S. P., Fremaux A. J., Sissia G., Cohen R., Geslin P. L., Bingen E. H. In vitro killing activities of antibiotics at clinically achievable concentrations in cerebrospinal fluid against penicillin-resistant Streptococcus pneumoniae isolated from children with meningitis. Antimicrob Agents Chemother. 1994 Nov;38(11):2655–2659. doi: 10.1128/aac.38.11.2655. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Friedland I. R., Paris M., Ehrett S., Hickey S., Olsen K., McCracken G. H., Jr Evaluation of antimicrobial regimens for treatment of experimental penicillin- and cephalosporin-resistant pneumococcal meningitis. Antimicrob Agents Chemother. 1993 Aug;37(8):1630–1636. doi: 10.1128/aac.37.8.1630. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. John C. C. Treatment failure with use of a third-generation cephalosporin for penicillin-resistant pneumococcal meningitis: case report and review. Clin Infect Dis. 1994 Feb;18(2):188–193. doi: 10.1093/clinids/18.2.188. [DOI] [PubMed] [Google Scholar]
  8. Klugman K. P., Koornhof H. J. Worldwide increase in pneumococcal antibiotic resistance. Lancet. 1989 Aug 19;2(8660):444–444. doi: 10.1016/s0140-6736(89)90617-x. [DOI] [PubMed] [Google Scholar]
  9. McCracken G. H., Jr, Sakata Y. Antimicrobial therapy of experimental meningitis caused by Streptococcus pneumoniae strains with different susceptibilities to penicillin. Antimicrob Agents Chemother. 1985 Feb;27(2):141–145. doi: 10.1128/aac.27.2.141. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Muñoz R., Coffey T. J., Daniels M., Dowson C. G., Laible G., Casal J., Hakenbeck R., Jacobs M., Musser J. M., Spratt B. G. Intercontinental spread of a multiresistant clone of serotype 23F Streptococcus pneumoniae. J Infect Dis. 1991 Aug;164(2):302–306. doi: 10.1093/infdis/164.2.302. [DOI] [PubMed] [Google Scholar]
  11. Nau R., Kaye K., Sachdeva M., Sande E. R., Täuber M. G. Rifampin for therapy of experimental pneumococcal meningitis in rabbits. Antimicrob Agents Chemother. 1994 May;38(5):1186–1189. doi: 10.1128/aac.38.5.1186. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Nau R., Schmidt T., Kaye K., Froula J. L., Täuber M. G. Quinolone antibiotics in therapy of experimental pneumococcal meningitis in rabbits. Antimicrob Agents Chemother. 1995 Mar;39(3):593–597. doi: 10.1128/AAC.39.3.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. París M. M., Hickey S. M., Trujillo M., Shelton S., McCracken G. H., Jr Evaluation of CP-99,219, a new fluoroquinolone, for treatment of experimental penicillin- and cephalosporin-resistant pneumococcal meningitis. Antimicrob Agents Chemother. 1995 Jun;39(6):1243–1246. doi: 10.1128/aac.39.6.1243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. París M. M., Ramilo O., McCracken G. H., Jr Management of meningitis caused by penicillin-resistant Streptococcus pneumoniae. Antimicrob Agents Chemother. 1995 Oct;39(10):2171–2175. doi: 10.1128/aac.39.10.2171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Scheld W. M. Quinolone therapy for infections of the central nervous system. Rev Infect Dis. 1989 Jul-Aug;11 (Suppl 5):S1194–S1202. doi: 10.1093/clinids/11.supplement_5.s1194. [DOI] [PubMed] [Google Scholar]
  16. Schlech W. F., 3rd, Ward J. I., Band J. D., Hightower A., Fraser D. W., Broome C. V. Bacterial meningitis in the United States, 1978 through 1981. The National Bacterial Meningitis Surveillance Study. JAMA. 1985 Mar 22;253(12):1749–1754. [PubMed] [Google Scholar]
  17. Spangler S. K., Jacobs M. R., Appelbaum P. C. Comparative activity of the new fluoroquinolone Bay y3118 against 177 penicillin susceptible and resistant pneumococci. Eur J Clin Microbiol Infect Dis. 1993 Dec;12(12):965–967. doi: 10.1007/BF01992176. [DOI] [PubMed] [Google Scholar]
  18. Spangler S. K., Jacobs M. R., Appelbaum P. C. Susceptibilities of penicillin-susceptible and -resistant strains of Streptococcus pneumoniae to RP 59500, vancomycin, erythromycin, PD 131628, sparfloxacin, temafloxacin, win 57273, ofloxacin, and ciprofloxacin. Antimicrob Agents Chemother. 1992 Apr;36(4):856–859. doi: 10.1128/aac.36.4.856. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Täuber M. G., Doroshow C. A., Hackbarth C. J., Rusnak M. G., Drake T. A., Sande M. A. Antibacterial activity of beta-lactam antibiotics in experimental meningitis due to Streptococcus pneumoniae. J Infect Dis. 1984 Apr;149(4):568–574. doi: 10.1093/infdis/149.4.568. [DOI] [PubMed] [Google Scholar]
  20. Täuber M. G., Kunz S., Zak O., Sande M. A. Influence of antibiotic dose, dosing interval, and duration of therapy on outcome in experimental pneumococcal meningitis in rabbits. Antimicrob Agents Chemother. 1989 Apr;33(4):418–423. doi: 10.1128/aac.33.4.418. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Viladrich P. F., Gudiol F., Liñares J., Pallarés R., Sabaté I., Rufí G., Ariza J. Evaluation of vancomycin for therapy of adult pneumococcal meningitis. Antimicrob Agents Chemother. 1991 Dec;35(12):2467–2472. doi: 10.1128/aac.35.12.2467. [DOI] [PMC free article] [PubMed] [Google Scholar]

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