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. 1997 Jun;41(6):1392–1395. doi: 10.1128/aac.41.6.1392

Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicans.

M E Klepser 1, E J Wolfe 1, R N Jones 1, C H Nightingale 1, M A Pfaller 1
PMCID: PMC163923  PMID: 9174207

Abstract

Time-kill curves were determined for three isolates of Candida albicans tested against fluconazole and amphotericin B at multiples of the MIC. Fluconazole produced fungistatic activity, with concentration-related growth effects observed over a narrow range of concentrations. Amphotericin B exhibited fungicidal activity, with enhancement of activity over a broader range of concentrations.

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Selected References

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