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. 1997 Jun;41(6):1396–1398. doi: 10.1128/aac.41.6.1396

Apparent involvement of a multidrug transporter in the fluoroquinolone resistance of Streptococcus pneumoniae.

N N Baranova 1, A A Neyfakh 1
PMCID: PMC163924  PMID: 9174208

Abstract

A Streptococcus pneumoniae strain selected for resistance to ethidium bromide demonstrated enhanced energy-dependent efflux of this toxic dye. Both the ethidium resistance and the ethidium efflux could be inhibited by the plant alkaloid reserpine. The ethidium-selected cells demonstrated cross-resistance to the fluoroquinolones norfloxacin and ciprofloxacin; this resistance could also be completely reversed by reserpine. Furthermore, reserpine potentiated the susceptibility of wild-type S. pneumoniae to fluoroquinolones and ethidium. The most plausible explanation for these results is that S. pneumoniae, like some other gram-positive bacteria, expresses a reserpine-sensitive multidrug transporter, which may play an important role in both intrinsic and acquired resistances of this pathogen to fluoroquinolone therapy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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