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. 1997 Jul;41(7):1601–1603. doi: 10.1128/aac.41.7.1601

Molecular analysis of katG gene mutations in strains of Mycobacterium tuberculosis complex from Africa.

W H Haas 1, K Schilke 1, J Brand 1, B Amthor 1, K Weyer 1, P B Fourie 1, G Bretzel 1, V Sticht-Groh 1, H J Bremer 1
PMCID: PMC163968  PMID: 9210694

Abstract

A sample of 124 isoniazid (INH)-resistant and 88 susceptible strains of Mycobacterium tuberculosis complex from south, central, and west Africa was analyzed by direct sequence analysis and PCR-restriction fragment length polymorphism analysis of their catalase-peroxidase (katG) genes. Point mutations at codon 315 were found in the genomes of 64% of INH-resistant strains, but no complete deletions were identified. Mutations at codon 463 were independent of INH resistance and were linked to the geographic origins of the strains.

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Selected References

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